Molecular imaging in early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases
| العنوان: | Molecular imaging in early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases |
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| المؤلفون: | Jochen Hammes, Alexander Drzezga, Gérard N. Bischof |
| المصدر: | Clinical and translational imaging 5(5), 465-471 (2017). doi:10.1007/s40336-017-0242-y |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Multimodal imaging, medicine.medical_specialty, Pathology, medicine.diagnostic_test, business.industry, Interventional radiology, Disease, Clinical trial, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neuroimaging, medicine, Radiology, Nuclear Medicine and imaging, ddc:610, Molecular imaging, Differential diagnosis, Intensive care medicine, business, Pathological, 030217 neurology & neurosurgery |
| الوصف: | Current disease models suggest that many neurodegenerative disorders are associated with pathological protein aggregations that start to develop in the brain long before the onset of clinical symptoms. Therefore, biomarkers allowing early and reliable characterization of neurodegenerative disease are required. Here we illustrate the potential value of neuroimaging procedures by means of selected examples. Multimodal imaging data of exemplary patients who underwent FDG, Amyloid and AV-1451-PET, FP-CIT-SPECT and MRI imaging in the routine clinical workup in our department is presented and the currently available literature on the topic of imaging in neurodegenerative diseases was reviewed. The complementary value of the applied imaging methods is demonstrated in pairs of representative cases. Depending on the clinical question, individual methods or a meaningful multimodal combination is required to achieve optimal diagnostic benefit. Imaging biomarkers have high potential for early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases already and will gain an even higher importance in the future, when specific pathology-targeted therapies will be evaluated in clinical trials. |
| تدمد: | 2281-7565 2281-5872 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dca2564331ec2068f18835e0d8c1ac https://doi.org/10.1007/s40336-017-0242-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....57dca2564331ec2068f18835e0d8c1ac |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22817565 22815872 |
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