Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness
| العنوان: | Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness |
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| المؤلفون: | Christoffer Polcwiartek, Adrian Pietersen, C A Barcella, Jonas B. Nielsen, Christian Torp-Pedersen, Peter Søgaard, Brett D. Atwater, Rubina Attar, Svend Eggert Jensen, Claus Graff, Kristian Kragholm, Daniel J. Friedman |
| المصدر: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Polcwiartek, C, Atwater, B D, Kragholm, K, Friedman, D J, Barcella, C A, Attar, R, Graff, C, Nielsen, J B, Pietersen, A, Søgaard, P, Torp-Pedersen, C & Jensen, S E 2021, ' Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness ', Journal of the American Heart Association, vol. 10, no. 2, e019416 . https://doi.org/10.1161/JAHA.120.019416 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adverse outcomes, Denmark, Population, Comorbidity, Disease, Primary care, Risk Assessment, Vulnerable Populations, Electrocardiography, primary care, risk prediction, Predictive Value of Tests, Risk Factors, severe mental illness, Internal medicine, mental disorders, Humans, Medicine, Arrhythmia and Electrophysiology, Registries, cardiovascular diseases, education, Association (psychology), Original Research, education.field_of_study, Primary Health Care, ECG, business.industry, Mental Disorders, Middle Aged, Prognosis, Mental illness, medicine.disease, Electrophysiology, Mental Health, Cardiovascular Diseases, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background ECG abnormalities are associated with adverse outcomes in the general population, but their prognostic significance in severe mental illness (SMI) remains unexplored. We investigated associations between no, minor, and major ECG abnormalities and fatal cardiovascular disease (CVD) among patients with SMI compared with controls without mental illness. Methods and Results We cross‐linked data from Danish nationwide registries and included primary care patients with digital ECGs from 2001 to 2015. Patients had SMI if they were diagnosed with schizophrenia, bipolar disorder, or severe depression before ECG recording. Controls were required to be without any prior mental illness or psychotropic medication use. Fatal CVD was assessed using hazard ratios (HRs) with 95% CIs and standardized 10‐year absolute risks. Of 346 552 patients, 10 028 had SMI (3%; median age, 54 years; male, 45%), and 336 524 were controls (97%; median age, 56 years; male, 48%). We observed an interaction between SMI and ECG abnormalities on fatal CVD ( P Conclusions ECG abnormalities conferred a poorer prognosis among patients with SMI compared with controls without mental illness. SMI patients with ECG abnormalities but no CVD represent a high‐risk population that may benefit from greater surveillance and risk management. |
| وصف الملف: | application/pdf |
| تدمد: | 2047-9980 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e0d37f423f02750be7105481261906 https://doi.org/10.1161/jaha.120.019416 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....57e0d37f423f02750be7105481261906 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20479980 |
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