Negri bodies and other virus membrane-less replication compartments
| العنوان: | Negri bodies and other virus membrane-less replication compartments |
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| المؤلفون: | Yves Gaudin, Aurélie A. Albertini, Cécile Lagaudrière-Gesbert, Quentin Nevers |
| المساهمون: | Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Rhabdovirus (RHABDO), Département Virologie (Dpt Viro), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ANR-19-CE15-0024,LiquidFact,Morphogenèse, organisation et fonctions des usines virales liquides formées par les Mononegavirales(2019) |
| المصدر: | Biochimica et Biophysica Acta-Molecular Cell Research Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2020, pp.118831. ⟨10.1016/j.bbamcr.2020.118831⟩ Biochimica et Biophysica Acta-Molecular Cell Research, 2020, pp.118831. ⟨10.1016/j.bbamcr.2020.118831⟩ Biochimica et Biophysica Acta. Molecular Cell Research |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | ISG, interferon-stimulated genes, viruses, [SDV]Life Sciences [q-bio], RNP, ribonucleoprotein, IB, inclusion body, Virus Replication, medicine.disease_cause, Inclusion bodies, Inclusion Bodies, Viral, Interferon, Viral factory, Liquid organelle, Viral replication, Mononegavirales, Innate immunity, 0303 health sciences, biology, Negri bodies, 030302 biochemistry & molecular biology, NB, Negri bodies, SG, stress granules, 3. Good health, Cell biology, VRC, viral replication center, EBOV, Ebola virus, Viral Replication Compartments, medicine.drug, VSV, vesicular stomatitis virus, Rabies, HPV, human papillomavirus, LLPS, liquid-liquid phase separation, Article, Virus, Viral Proteins, 03 medical and health sciences, EBV, Epstein Barr virus, medicine, IFN, interferon, Molecular Biology, 030304 developmental biology, HCMV, human cytomegalovirus, Membrane-less compartment, PML, promyelocytic leukemia protein, MuV, mumps virus, RABV, rabies virus, Cell Membrane, Rabies virus, MeV, measles virus, Cell Biology, biology.organism_classification, NiV, Nipah virus, ADV, adenovirus, RSV, respiratory syncytial virus, MNV, Mononegavirales, IDD, intrinsically disordered domain |
| الوصف: | Viruses reshape the organization of the cell interior to achieve different steps of their cellular cycle. Particularly, viral replication and assembly often take place in viral factories where specific viral and cellular proteins as well as nucleic acids concentrate. Viral factories can be either membrane-delimited or devoid of any cellular membranes. In the latter case, they are referred as membrane-less replication compartments. The most emblematic ones are the Negri bodies, which are inclusion bodies that constitute the hallmark of rabies virus infection. Interestingly, Negri bodies and several other viral replication compartments have been shown to arise from a liquid-liquid phase separation process and, thus, constitute a new class of liquid organelles. This is a paradigm shift in the field of virus replication. Here, we review the different aspects of membrane-less virus replication compartments with a focus on the Mononegavirales order and discuss their interactions with the host cell machineries and the cytoskeleton. We particularly examine the interplay between viral factories and the cellular innate immune response, of which several components also form membrane-less condensates in infected cells. Highlights • Viral factories harbor essential steps of the viral cycle. • Some viral factories are devoid of membranes and have liquid organelle properties. • Liquid viral factories concentrate cellular factors required for replication. • Innate immunity sensors and several ISGs are found in membrane-less condensates. • A subtle interplay exists between liquid viral factories and innate immunity actors. |
| اللغة: | English |
| تدمد: | 0167-4889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e424459d675de4ad50f0a9a5a75c14 https://hal.archives-ouvertes.fr/hal-02928156/file/main.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....57e424459d675de4ad50f0a9a5a75c14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01674889 |
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