Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition
| العنوان: | Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition |
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| المؤلفون: | Ge-Liang Xu, Yan-Ru Deng, Jing Chen, Jian-Sheng Li, Wen-Bin Liu, Jin-Liang Ma, Wei-Dong Jia, Mei Huang |
| المصدر: | International Journal of Oncology. 44:247-255 |
| بيانات النشر: | Spandidos Publications, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Angiogenesis, Vimentin, Metastasis, Neovascularization, Cell Line, Tumor, Biomarkers, Tumor, medicine, Humans, HSP70 Heat-Shock Proteins, Epithelial–mesenchymal transition, Aged, Neoplasm Staging, Aged, 80 and over, Neovascularization, Pathologic, biology, Oncogene, Liver Neoplasms, Middle Aged, Cell cycle, medicine.disease, Molecular medicine, digestive system diseases, Gene Expression Regulation, Neoplastic, Oncology, biology.protein, Cancer research, Female, medicine.symptom |
| الوصف: | Mortalin is highly expressed in a variety of human tumors and associated with tumor metastasis. However, the relationship among the overexpression of Mortalin, epithelial to mesenchymal transition (EMT) and neovascularization is largely unknown. The aim of the present study was to investigate the expression of Mortalin in human HCC cell lines, clinical HCC specimens and its association with angiogenesis and EMT. The results of our study showed that the expression levels of Mortalin in cell lines with higher metastatic potential were significantly higher compared to those with lower metastatic potential. Compared with paracarcinomatous tissues and normal liver tissues, the expression of Mortalin was significantly increased in HCC tumor tissues. The expression of Mortalin was correlated with invasion and metastasis, Edmondson grade and TNM stage. A significant positive correlation was found between the expression of Mortalin and Vimentin, and tumors with high expression of Mortalin had a tendency to higher MVD compared to those with low expression of Mortalin. Using shRNA-mediated Mortalin knockdown, we found that decreased expression of Mortalin was accompanied by a reduction of Vimentin expression. Our findings demonstrated that the overexpression of Mortalin is correlated with the metastatic phenotype of HCC cells and can promote EMT, but cannot induce angiogenesis in HCC. The decreased expression of Mortalin is accompanied by an inhibition of EMT in the HCC cell lines. |
| تدمد: | 1791-2423 1019-6439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582c4de16c9d7e78725afcd7341b75c5 https://doi.org/10.3892/ijo.2013.2161 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....582c4de16c9d7e78725afcd7341b75c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912423 10196439 |
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