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Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

التفاصيل البيبلوغرافية
العنوان: Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis
المؤلفون: Lia Lajuna, Cut Yuniwati, Oktalia Sabrida, Maharani Maharani, Sutrisno Sutrisno
المصدر: Journal of Ayurveda and Integrative Medicine
Journal of Ayurveda and Integrative Medicine, Vol 12, Iss 2, Pp 229-233 (2021)
سنة النشر: 2019
مصطلحات موضوعية: Cell death, Programmed cell death, Angiogenesis, Endometriosis lesions, Flavonoid, Proliferation, 0211 other engineering and technologies, Endometriosis, 02 engineering and technology, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Phaleria macrocarpa, 021105 building & construction, Drug Discovery, medicine, Miscellaneous systems and treatments, chemistry.chemical_classification, Flavonoids, biology, business.industry, fungi, RZ409.7-999, food and beverages, medicine.disease, biology.organism_classification, 030205 complementary & alternative medicine, Complementary and alternative medicine, chemistry, Apoptosis, Granuloma, Original Research Article (Experimental), Immunohistochemistry, Peritoneum, business
الوصف: Background Endometriois represents a gynecological disease that still becomes an issue in community. Phaleria macrocarpa is a plant native to Indonesia that contains an antioxidant substance, which may serve as apoptotic modulator and useful for angiogenesis. Objective This study aims to evaluate the effects of flavonoid isolates from P. macrocarpa (PM) on the development of granulomas, apoptosis, proliferation, and angiogenesis of the disease. Material and methods Total thirty mice (Mus musculus) were categorized into six groups, including the normal group (without any treatment), EMT (endometriosis) group, and EMT group treated with PM flavonoid isolates. Identification of the active compounds of P. macrocarpa was done using LC-HRMS. Measurement of granuloma scores and vascular density was done histologically. Apoptosis and proliferation analysis was performed by immunohistochemical techniques. Results There was an increase in granulomas, proliferation, and apoptosis in the peritoneal tissues of the endometriosis model. This change can be normalized by extract of P. macrocarpa. Conclusion We concluded that the flavonoid isolates from P. macrocarpa can suppress the growth of endometriosis lesions through normalization of proliferation and apoptosis. Thus, the P. macrocarpa flavonoid can be used as an alternative to inhibit the development of endometriosis.
تدمد: 0975-9476
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586274c967740deb42d491f88bb1e8ad
https://pubmed.ncbi.nlm.nih.gov/33288353
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....586274c967740deb42d491f88bb1e8ad
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09759476