BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia
| العنوان: | BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia |
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| المؤلفون: | Eloisa Jantus Lewintre, Jehzabel Pendas, José Ramón Mayans Ferrer, Javier García-Conde, Cristina Reinoso Martín, Carmen Benet Campos, Carlos García Ballesteros |
| المصدر: | Leukemia & Lymphoma. 50:773-780 |
| بيانات النشر: | Informa UK Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Somatic cell, Chronic lymphocytic leukemia, Biology, Predictive Value of Tests, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Point Mutation, Gene, Aged, Aged, 80 and over, Polymorphism, Genetic, Genes, Immunoglobulin, Germinal center, Hematology, Middle Aged, Prognosis, medicine.disease, BCL6, Leukemia, Lymphocytic, Chronic, B-Cell, DNA-Binding Proteins, Treatment Outcome, Real-time polymerase chain reaction, Oncology, Mutation, Immunology, Proto-Oncogene Proteins c-bcl-6, biology.protein, Female, Antibody, Immunoglobulin Heavy Chains, IGHV@ |
| الوصف: | BCL6 somatic mutations affect normal and tumoral post germinal center B-lymphocytes. Our objective was to analyse expression, mutations and polymorphisms in the BCL6 gene and to correlate those variables with the clinical outcome in early-stage chronic lymphocytic leukemia (CLL). CLL samples were used for characterisation of the mutational status of BCL6/ immunoglobulin variable heavy chain (IGHV) genes, and expression of BCL6 was determined by real time PCR and immunoblot. Out of 68 cases, 29% show somatic mutations on BCL6 which occur exclusively in IGHV mutated cases. They are single nucleotide substitutions located mainly in two short mutational hot spots. CLL cells express different levels of BCL6 regardless of the mutational status, the number of mutations and polymorphisms. CLL cases expressing high levels of BCL6 have significantly shorter treatment-free interval. In conclusion, in early-stage patients with CLL, we found no correlation between expression and the mutations or polymorphism in BCL6, but high levels of BCL6 can discriminate patients with a worse prognosis. |
| تدمد: | 1029-2403 1042-8194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5864a5e9306b800e3d1feb807a766dea https://doi.org/10.1080/10428190902842626 |
| رقم الأكسشن: | edsair.doi.dedup.....5864a5e9306b800e3d1feb807a766dea |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 10292403 10428194 |
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