Use of Eltrombopag in Improving Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation
| العنوان: | Use of Eltrombopag in Improving Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation |
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| المؤلفون: | Ashish Dwary, Nebu Koshy, Richard Mansour, Samip Master, Glenn Mills |
| المصدر: | Case Reports in Oncology, Vol 11, Iss 1, Pp 191-195 (2018) Case Reports in Oncology |
| بيانات النشر: | Karger Publishers, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Anemia, medicine.medical_treatment, Eltrombopag, Case Report, Hematopoietic stem cell transplantation, lcsh:RC254-282, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Aplastic anemia, Thrombopoietin, Acute myeloid leukemia, business.industry, Allogenic transplant, Stem cell transplantation, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Haematopoiesis, Oncology, chemistry, 030220 oncology & carcinogenesis, Immunology, Absolute neutrophil count, Stem cell, business, 030215 immunology |
| الوصف: | Eltrombopag is a thrombopoietin agonist and has been used in aplastic anemia and post-transplantation thrombocytopenia. The c-MPL receptor is present on hematopoietic stem cells. There are no reports of eltrombopag utilization for improving poor graft function in the post-transplant setting. Here were report a case of a young female with post-transplant poor graft function as evident from the low absolute neutrophil count, anemia, and thrombocytopenia on day 60. Eltrombopag was started on day 72 and resulted in improvement in all 3 cell lines. The counts continued to be stable even after eltrombopag was discontinued. The patient tolerated the drug without significant side effects for 1 year. |
| اللغة: | English |
| تدمد: | 1662-6575 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58708978d3d3c5f6fccba8dd26ca8791 https://www.karger.com/Article/FullText/487229 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....58708978d3d3c5f6fccba8dd26ca8791 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16626575 |
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