Influence of Pyrexia on Pharmacokinetics of Azithromycin and Its Interaction With Tolfenamic Acid in Goats
| العنوان: | Influence of Pyrexia on Pharmacokinetics of Azithromycin and Its Interaction With Tolfenamic Acid in Goats |
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| المؤلفون: | Sini Mechery, Kanjirakuzhiyil Promod, Suresh Narayanan Nair, Thirumangalath Meethal Divya, Sakkariya Ibrahim Nalukudy Paramba, Sanis Juliet, Reghu Ravindran |
| المصدر: | Frontiers in Veterinary Science Frontiers in Veterinary Science, Vol 8 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | half-life, 040301 veterinary sciences, Veterinary medicine, clearance, Azalide, Pharmacology, Azithromycin, 0403 veterinary science, 03 medical and health sciences, Tolfenamic acid, Pharmacokinetics, SF600-1100, medicine, Antipyretic, 030304 developmental biology, Original Research, blood concentration, Volume of distribution, 0303 health sciences, General Veterinary, Chemistry, Area under the curve, 04 agricultural and veterinary sciences, Drug interaction, mean residence time, Veterinary Science, non-compartmental, HPLC, medicine.drug |
| الوصف: | Azithromycin is a macrolide antimicrobial agent of the azalide group with a broad spectrum of activity against gram-negative and gram-positive bacterial organisms. Tolfenamic acid is a non-steroidal anti-inflammatory drug of the fenamate group, which is used extensively in humans and animals due to its anti-inflammatory, analgesic, and antipyretic properties. There is dearth of literature on any type of drug interaction between azithromycin and tolfenamic acid in any species, including human beings and alteration of its pharmacokinetics by fever. Therefore, the objective of this study was to investigate the alteration of disposition kinetics of azithromycin alone and in the presence of tolfenamic acid in Malabari goats by fever, following an intravenous administration at a dose rate of 20 mg/kg body weight. Blood samples collected from both afebrile and febrile goats at predetermined time intervals after the administration of azithromycin alone and then in combination with tolfenamic acid (2 mg/kg, intravenously), respectively, were analyzed using high-performance liquid chromatography. Non-compartmental analysis was used to determine the peak blood concentration (Cmax), time-to-peak plasma concentration (Tmax), half-life (t1/2λz), area under the curve (AUC0−t, AUC0−inf), area under the first moment curve (AUMC0−inf), mean residence time (MRT0−inf), apparent volume of distribution at steady state (Vss), and the total body clearance of drug from the blood (Cl). In febrile animals, significant differences were noted in the values ofCmax, Cl, andVss. Thus, azithromycin disappears into an additional compartment in febrile goats, which may be due to its extended cellular penetration into the inflammatory cells, resulting in anti-inflammatory activity. Tolfenamic acid significantly altered the pharmacokinetics of azithromycin in both normal and febrile animals. Tolfenamic acid, being a better anti-inflammatory agent, suppresses the inflammatory mediators, reducing the possibility of increased utilization of azithromycin in febrile condition. |
| اللغة: | English |
| تدمد: | 2297-1769 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5876f9b452a20dde33034b9018d4f57c http://europepmc.org/articles/PMC8222727 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5876f9b452a20dde33034b9018d4f57c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22971769 |
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