Usefulness of patient-reported outcomes to assess the effectiveness of topical hormonal therapy for gynecologic symptoms after antihormonal treatment for breast cancer
| العنوان: | Usefulness of patient-reported outcomes to assess the effectiveness of topical hormonal therapy for gynecologic symptoms after antihormonal treatment for breast cancer |
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| المؤلفون: | Mark Walker, Justin R. Smith, Gregory A. Vidal, Julie Ryder, Amit L Jain, Emily Miller, Omer Jamy, Poojitha Valasareddy, Edward J. Stepanski, Felicia Hare, Janice Nhan Mullins, Harsha Ranganath, Justin Gatwood, Rana Muhammad Usman, Lee S. Schwartzberg, Amina Chaudhry |
| المصدر: | Proc (Bayl Univ Med Cent) |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, business.industry, Retrospective cohort study, General Medicine, medicine.disease, humanities, Breast cancer, Internal medicine, medicine, Hormonal therapy, Atrophic Vaginitis, business, Original Research, Hormone |
| الوصف: | The aim of this retrospective study was to assess the efficacy of topical hormonal therapy (THT) to relieve vaginal symptoms resulting from antihormonal therapy in women with hormone receptor–positive breast cancer. A total of 74 breast cancer patients who received THT for vaginal complaints were retrospectively identified and statistically matched with 74 control breast cancer patients with vaginal complaints with no documented use of THT. Symptom scores were recorded from the center’s proprietary patient-reported outcomes database, Patient Care Monitor (ConcertoHealthAI, Boston). A baseline score was noted at the initiation of antihormonal therapy and was followed at 6 and 12 months. The median differences between baseline, 6-month, and 12-month scores were analyzed. Repeated measures analysis of variance assessed the impact of topical hormonal replacement. There was no statistically significant difference in score change between the two groups at 6 and 12 months. In the active THT group, there were no statistically significant differences in vaginal complaints or sexual problems over time: {F (2, 146) = 0.99, P = 0.369; and F (2, 146) = 1.56, P = 0.217}, respectively. In this study, the use of topical hormonal replacement was not effective in alleviating vaginal symptoms. |
| تدمد: | 1525-3252 0899-8280 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5888429ea85cb97d94700d2d5d5f54c0 https://doi.org/10.1080/08998280.2020.1744059 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5888429ea85cb97d94700d2d5d5f54c0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15253252 08998280 |
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