Comparison of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pressure Ulcer in a Rat Model
| العنوان: | Comparison of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pressure Ulcer in a Rat Model |
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| المؤلفون: | Ze Yuan, Yanxue Wang, Yudan Li, Caina Lin, Shaoling Wang, Junchao Wang, Chao Ma, Shaoling Wu |
| المصدر: | Journal of Burn Care & Research. |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Rehabilitation, Emergency Medicine, Surgery |
| الوصف: | Pressure ulcer (PU) is a common type of chronic wound that is difficult to treat. Platelet-rich plasma (PRP) is rich in cytokines and growth factors, and it can be divided into two categories according to its leukocyte content: leukocyte-poor PRP (P-PRP) and leukocyte-rich PRP (L-PRP). PRP has been applied in a variety of wound treatments, due to its strong ability to promote repair. This study aims to investigate the therapeutic effects of PRP on PU and elucidate the role of leukocytes in the treatment process. Sprague-Dawley rats were used to establish PU models of ischemia–reperfusion injury by applying magnets externally. L-PRP, P-PRP, and saline were injected into the dermal wounds. Wound healing analysis and sampling were performed on days 3, 7, 11, and 15 after treatment. Histological examinations, real-time PCR, immunohistochemical examinations, and biomechanical assay were carried out on the wound samples. The PRP groups exhibited greater wound inflammatory response than the control group in the early stage but the response reduced rapidly as the wound healed. On days 7, 11, and 15, the PRP groups also yielded better wound healing rates and histological outcomes than the control group, with superior biomechanical properties observed on day 15. Among both PRP groups, the L-PRP group attained a higher wound healing rate than the P-PRP group on day 7, with greater significant early inflammatory responses, and more prominent angiogenesis. Therefore, PRP is proven to accelerate the healing of PU, with L-PRP being more effective in regulating inflammation and promoting angiogenesis than P-PRP. |
| تدمد: | 1559-0488 1559-047X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c529eb6a453f97fb038a016d8f4af4 https://doi.org/10.1093/jbcr/irac191 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....58c529eb6a453f97fb038a016d8f4af4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590488 1559047X |
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