Induction of labor compared to expectant management in term nulliparas with a latent phase of labor of more than 8 hours: a randomized trial
| العنوان: | Induction of labor compared to expectant management in term nulliparas with a latent phase of labor of more than 8 hours: a randomized trial |
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| المؤلفون: | Lindy Li Mei Bak, Sandar Tin Win, Narayanan Vallikkannu, Siti Zawiah Omar, Patrick Naveen Sargunam, Mat Adenan Noor Azmi, Peng Chiong Tan, Syeda Zaidi |
| المصدر: | BMC Pregnancy and Childbirth, Vol 19, Iss 1, Pp 1-8 (2019) BMC Pregnancy and Childbirth |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Time Factors, Latent phase of labor, medicine.medical_treatment, Cervical dilation, Nullipara, Cesarean, Uterine hyperstimulation, lcsh:Gynecology and obstetrics, law.invention, 03 medical and health sciences, 0302 clinical medicine, Patient satisfaction, Randomized controlled trial, law, Pregnancy, medicine, Humans, 030212 general & internal medicine, Labor, Induced, Watchful Waiting, Vaginal delivery, lcsh:RG1-991, Full Term, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Cesarean Section, Obstetrics and Gynecology, Term, Dystocia, Parity, Treatment Outcome, Labor induction, Gestation, Female, Expectant management, business, Induction of labor, Research Article |
| الوصف: | Background Prolonged latent phase of labor is associated with adverse maternal and neonatal outcomes. Preliminary data indicate that labor induction for prolonged latent phase may reduce cesarean delivery. We performed a study powered to Cesarean delivery to evaluate labor induction compared to expectant management in full term nulliparas hospitalized for persistent contractions but non-progressive to established labor after an overnight stay. Methods From 2015 and 2017, nulliparas, ≥ 39 weeks’ gestation with prolonged latent phase of labor (persistent contractions after overnight hospitalization > 8 h), cervical dilation ≤3 cm, intact membranes and reassuring cardiotocogram were recruited. Participants were randomized to immediate induction of labor (with vaginal dinoprostone or amniotomy or oxytocin as appropriate) or expectant management (await labor for at least 24 h unless indicated intervention as directed by care provider). Primary outcome measure was Cesarean delivery. Results Three hundred eighteen women were randomized (159 to each arm). Data from 308 participants were analyzed. Cesarean delivery rate was 24.2% (36/149) vs. 23.3%, (37/159) RR 1.0 95% CI 0.7–1.6; P = 0.96 in induction of labor vs. expectant arms. Interval from intervention to delivery was 17.1 ± 9.9 vs. 40.1 ± 19.8 h; P P P P P = 0.01 in IOL compared with expectant arms respectively. Intrapartum oxytocin use, epidural analgesia and uterine hyperstimulation syndrome, postpartum hemorrhage, patient satisfaction on allocated intervention, during labor and delivery and baby outcome were not significantly different across trial arms. Conclusions Induction of labor did not reduce Cesarean delivery rates but intervention to delivery and to hospital discharge durations are shorter. Patient satisfaction scores were similar. Induction of labor for prolonged latent phase of labor can be performed without apparent detriment to expedite delivery. Trial registration Registered in Malaysia National Medical Research Register (NMRR-15-16-23,886) on 6 January 2015 and the International Standard Randomised Controlled Trials Number registry, registration number ISRCTN14099170 on 5 Nov 2015. |
| اللغة: | English |
| تدمد: | 1471-2393 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e39eef7d0f2681fc0dd2b23a58d2c2 https://doaj.org/article/99f55926f876470daaa6bea1cfdfb262 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....58e39eef7d0f2681fc0dd2b23a58d2c2 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712393 |
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