Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit
| العنوان: | Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit |
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| المؤلفون: | Chia-Hung Wu, Wan You Guo, Wei Hsin Yuan, Hui-Chen Hsu, Shu Yi Yu, Ying Yuan Chen, Anna Fen Yau Li, Jiing Feng Lirng |
| المصدر: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2425, p 2425 (2020) Volume 9 Issue 8 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, genetic structures, medicine.medical_treatment, lcsh:Medicine, Orbital lymphoma, computed tomography (CT), Gastroenterology, Immunoglobulin G, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Precontrast, Hounsfield scale, Internal medicine, parasitic diseases, orbital lymphoma (OL), medicine, Hounsfield unit, immunoglobulin G4-related orbital disease (IgG4-ROD), Chemotherapy, integumentary system, biology, business.industry, fungi, lcsh:R, General Medicine, medicine.disease, Confidence interval, Lymphoma, Radiation therapy, 030221 ophthalmology & optometry, biology.protein, sense organs, business |
| الوصف: | Background: Benign immunoglobulin G4 (IgG4)-related orbital disease (IgG4-ROD)&mdash characterized as tumors mimicking malignant orbital lymphoma (OL)&mdash responds well to steroids, instead of chemotherapy, radiotherapy and/or surgery of OL. The objective of this study was to report the differences in computed tomography (CT) features and- serum IgG4 levels of IgG4-ROD and OL. Methods: This study retrieved records for patients with OL and IgG4-ROD from a pathology database during an eight-year-and-five-month period. We assessed the differences between 16 OL patients with 27 lesions and nine IgG4-ROD patients with 20 lesions according to prebiopsy CT features of lesions and prebiopsy serum IgG4 levels and immunoglobulin G (IgG) levels This study also established the receiver-operating curves (ROC) of precontrast and postcontrast CT Hounsfield unit scales (CTHU), serum IgG4 levels, serum IgG levels and their ratios. Results: Significantly related to IgG4-ROD (all p < 0.05) were the presence of lesions with regular borders, presence of multiple lesions&mdash involving both lacrimal glands on CT scans&mdash higher median values of postcontrast CTHU, postcontrast CTHU/precontrast CTHU ratios, serum IgG4 levels and serum IgG4/IgG level ratios. Compared to postcontrast CTHU, serum IgG4 levels had a larger area under the ROC curve (0.847 [95% confidence interval (CI): 0.674&ndash 1.000, p = 0.005] vs. 0.766 [95% CI: 0.615&ndash 0.917, p = 0.002]), higher sensitivity (0.889 [95% CI: 0.518&ndash 0.997] vs. 0.75 [95% CI: 0.509&ndash 0.913]), higher specificity (0.813 [95% CI: 0.544&ndash 0.960] vs. 0.778 [95% CI: 0.578&ndash 0.914]) and a higher cutoff value (&ge 132.5 mg/dL [milligrams per deciliter] vs. &ge 89.5). Conclusions: IgG4-ROD showed distinct CT features and elevated serum IgG4 (&ge 132.5 mg/dL), which could help distinguish IgG4-ROD from OL. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f2146ee54a817c4b544d19b7103181 https://pubmed.ncbi.nlm.nih.gov/32751135 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....58f2146ee54a817c4b544d19b7103181 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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