The effects of lycopene on intestinal injury due to methotrexate in rats
| العنوان: | The effects of lycopene on intestinal injury due to methotrexate in rats |
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| المؤلفون: | Suzan Tabur, Abdullah Ozgonul, Sezen Kocarslan, Ahmet Şeker, Nurten Aksoy, Alpay Aktümen, Emin Savik, Yusuf Yucel, Ali Uzunkoy, Hasan Büyükaslan, Orhan Gozeneli |
| المصدر: | Redox Report. 21:113-118 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, musculoskeletal diseases, Physiology, Interleukin-1beta, Clinical Biochemistry, Pharmacology, medicine.disease_cause, Biochemistry, Antioxidants, Oral gavage, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Lycopene, 0302 clinical medicine, Malondialdehyde, Sprague dawley rats, Animals, Medicine, Intestinal Mucosa, Tumor Necrosis Factor-alpha, business.industry, Biochemistry (medical), Cell Biology, Carotenoids, Glutathione, Rats, Intestines, Oxidative Stress, Methotrexate, chemistry, 030220 oncology & carcinogenesis, Intestinal injury, 030211 gastroenterology & hepatology, Tumor necrosis factor alpha, business, Corn oil, Oxidative stress, Research Article, medicine.drug |
| الوصف: | Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats. Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L. Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI). Results: Mtx administration increased histopathological damage and increased TNF-α, IL-1β, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1β, TOS, and OSI in the intestinal tissues. Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1β) levels. |
| تدمد: | 1743-2928 1351-0002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590296405e648acd5db80ac76deca7f2 https://doi.org/10.1179/1351000215y.0000000041 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....590296405e648acd5db80ac76deca7f2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17432928 13510002 |
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