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Evaluation of propylene glycol nanoliposomes containing curcumin on burn wound model in rat: biocompatibility, wound healing, and anti-bacterial effects

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العنوان: Evaluation of propylene glycol nanoliposomes containing curcumin on burn wound model in rat: biocompatibility, wound healing, and anti-bacterial effects
المؤلفون: Homanaz Ghafari, Alireza Partoazar, Ahmad Reza Dehpour, Nooshin Kianvash, Maryam Pourhajibagher, Vahid Nikoui, Abbas Bahador, Sayed Mehdi Rezayat
المصدر: Drug Delivery and Translational Research. 7:654-663
بيانات النشر: Springer Science and Business Media LLC, 2017.
سنة النشر: 2017
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Curcumin, Biocompatibility, Administration, Topical, Chemistry, Pharmaceutical, Biological Availability, Pharmaceutical Science, 02 engineering and technology, Pharmacology, Administration, Cutaneous, Silver sulfadiazine, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, medicine, Animals, Humans, Particle Size, Wound Healing, Burn therapy, Chemistry, 021001 nanoscience & nanotechnology, Effective dose (pharmacology), Rats, Bioavailability, Surgery, Disease Models, Animal, 030104 developmental biology, Propylene Glycols, Liposomes, Rabbits, Nanocarriers, Burns, 0210 nano-technology, Wound healing, medicine.drug
الوصف: Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior. TEM analysis of nanocarriers showed no aggregation in long time storage up to 60 days. The biocompatibility of the Cur-PgL formulation was evaluated by ISO standards. We found that Cur-PgL 0.3% was the effective dose in injured rats without any side effects on intact skin. The cytotoxicity of the Cur-PgL 0.3% nanovesicles was also assessed on human dermal fibroblast (HDF) cells. The results showed no detectable cytotoxicity, but considerable cytotoxicity was observed in higher concentration of 1.5 and 3 mg/ml of free and PgL forms of curcumin. Eight days of application of Cur-PgL on burned rats resulted in a significant (P
تدمد: 2190-3948
2190-393X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5921d75d93e814e58e4392cb4a32ae91
https://doi.org/10.1007/s13346-017-0405-4
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....5921d75d93e814e58e4392cb4a32ae91
قاعدة البيانات: OpenAIRE
الوصف
تدمد:21903948
2190393X