Efficacy and acceptability of the new oral phosphate binder L enziaren ® in healthy cats fed a renal diet
| العنوان: | Efficacy and acceptability of the new oral phosphate binder |
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| المؤلفون: | Jonathan N. King, H. G. Luus, H. L. Erasmus, P. M. Barnes, Cindy Speranza, P. C. Delport |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics. 38:278-289 |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Dose, medicine.drug_class, Administration, Oral, Urine, Placebo, Ferric Compounds, Feed conversion ratio, Phosphates, Excretion, Blood serum, Animal science, Lanthanum, Internal medicine, medicine, Animals, Pharmacology, CATS, Dose-Response Relationship, Drug, General Veterinary, business.industry, Starch, Diet, Phosphate binder, Drug Combinations, Treatment Outcome, Endocrinology, Cats, Female, business |
| الوصف: | The efficacy and acceptability of the new oral phosphate binder Lenziaren(®) (SBR759) were evaluated in healthy cats fed with a commercial diet containing low amounts of phosphate ('renal diet'). Lenziaren(®) at 0.125, 0.25, 0.5 and 1 g/day was compared to a reference product Lantharenol(®) (3.0 g/day) and a placebo in a masked, randomized, parallel-group design study in 36 cats (n = 6 per group). All products were mixed with the ration which was fed once daily for 28 days. Lenziaren(®) produced significant dose-related reductions in serum and urine phosphate concentrations, faecal apparent phosphorus digestibility and fractional urinary phosphate excretion. Cats administered Lenziaren(®) consumed significantly less food than the placebo group, but this had no negative impact on body weight or acceptability assessments. When compared to the positive control, Lantharenol(®) , Lenziaren(®) was significantly more acceptable (0.125, 0.5 and 1.0 g/day doses), was associated with higher food consumption (0.125, 0.5 and 1.0 g/day doses) and had greater efficacy in reducing serum phosphate (0.5 and 1.0 g/day) and urine phosphate concentrations (1.0 g/day). In conclusion, Lenziaren(®) was an effective oral phosphate binder in healthy cats fed with a renal diet. Lenziaren(®) was well accepted and tolerated. Dosages of 0.25-1.0 g/cat per day are recommended for clinical testing. |
| تدمد: | 1365-2885 0140-7783 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59360e2128b51313714af3797e57ccbe https://doi.org/10.1111/jvp.12173 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....59360e2128b51313714af3797e57ccbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652885 01407783 |
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