Blood
| العنوان: | Blood |
|---|---|
| المؤلفون: | Gerald E. Byrne, Edward W. Harhaj, Valentine B Andela, Isildinha M. Reis, Lee Ratner, William J. Harrington, Phillip Ruiz, Celia Pedroso, Ngoc L. Toomey, Carlos Brites, Juan Carlos Ramos, Izidore S. Lossos |
| المصدر: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| بيانات النشر: | American Society of Hematology, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Immunology, Gene Expression, Alpha interferon, Biology, Antiviral Agents, Proto-Oncogene Mas, Biochemistry, Adult T-cell leukemia/lymphoma, Cohort Studies, Maintenance therapy, Internal medicine, Drug Resistance, Viral, medicine, Humans, Leukemia-Lymphoma, Adult T-Cell, Aged, Hematology, Neoplasia, NF-kappa B, Nuclear Proteins, Cell Biology, Gene rearrangement, Middle Aged, medicine.disease, Proto-Oncogene Proteins c-rel, Recombinant Proteins, Lymphoma, DNA-Binding Proteins, Leukemia, Interferon Regulatory Factors, Interferon Type I, Genes, rel, Zidovudine, Interferon type I, medicine.drug |
| الوصف: | Texto completo: acesso restrito. p. 3060-3068 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-31T13:36:44Z No. of bitstreams: 1 10.1182blood-2006-07-036368.pdf: 462922 bytes, checksum: c202f28ba32075e6e84fa317bb140cba (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T15:58:20Z (GMT) No. of bitstreams: 1 10.1182blood-2006-07-036368.pdf: 462922 bytes, checksum: c202f28ba32075e6e84fa317bb140cba (MD5) Made available in DSpace on 2014-09-09T15:58:20Z (GMT). No. of bitstreams: 1 10.1182blood-2006-07-036368.pdf: 462922 bytes, checksum: c202f28ba32075e6e84fa317bb140cba (MD5) Previous issue date: 2007 Adult T-cell leukemia/lymphoma (ATLL) is a generally fatal malignancy. Most ATLL patients fare poorly with conventional chemotherapy; however, antiviral therapy with zidovudine (AZT) and interferon alpha (IFN-α) has produced long-term clinical remissions. We studied primary ATLL tumors and identified molecular features linked to sensitivity and resistance to antiviral therapy. Enhanced expression of the proto-oncogene c-Rel was noted in 9 of 27 tumors. Resistant tumors exhibited c-Rel (6 of 10; 60%) more often than did sensitive variants (1 of 9; 11%). This finding was independent of the disease form. Elevated expression of the putative c-Rel target, interferon regulatory factor-4 (IRF-4), was observed in 10 (91%) of 11 nonresponders and in all tested patients with c-Rel+ tumors and occurred in the absence of the HTLV-1 oncoprotein Tax. In contrast, tumors in complete responders did not express c-Rel or IRF-4. Gene rearrangement studies demonstrated the persistence of circulating T-cell clones in long-term survivors maintained on antiviral therapy. The expression of nuclear c-Rel and IRF-4 occurs in the absence of Tax in primary ATLL and is associated with antiviral resistance. These molecular features may help guide treatment. AZT and IFN-α is a suppressive rather than a curative regimen, and patients in clinical remission should remain on maintenance therapy indefinitely. |
| تدمد: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2006-07-036368 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59384276deebe5e5375e5bbaa02e0ff3 https://doi.org/10.1182/blood-2006-07-036368 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....59384276deebe5e5375e5bbaa02e0ff3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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| DOI: | 10.1182/blood-2006-07-036368 |