New Recombinant Carriers Binding Specifically to the Epidermal Growth Factor Receptor
| العنوان: | New Recombinant Carriers Binding Specifically to the Epidermal Growth Factor Receptor |
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| المؤلفون: | Alexander S. Sobolev, Andrey A. Rosenkranz, Tatiana S. Karyagina, Yuri V. Khramtsov, Georgii P. Georgiev, Alexey V. Ulasov, Tatiana A. Slastnikova, T. N. Lupanova |
| المصدر: | Doklady Biochemistry and Biophysics. 490:22-24 |
| بيانات النشر: | Pleiades Publishing Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cell, Biophysics, Antineoplastic Agents, Ligands, Biochemistry, law.invention, 03 medical and health sciences, Drug Delivery Systems, Protein Domains, law, Cell Line, Tumor, medicine, Humans, Cytotoxic T cell, Epidermal growth factor receptor, Cell Proliferation, 030304 developmental biology, Cell Nucleus, 0303 health sciences, Epidermal Growth Factor, biology, Human epidermal growth factor, Chemistry, Indium Radioisotopes, 030302 biochemistry & molecular biology, Auger electron emitter, General Chemistry, General Medicine, Ligand (biochemistry), Recombinant Proteins, Cell biology, ErbB Receptors, medicine.anatomical_structure, Cancer cell, MCF-7 Cells, Recombinant DNA, biology.protein, Protein Binding |
| الوصف: | New recombinant carriers-modular nanotransporters (MNTs)-with N-terminal ligand module to the epidermal growth factor receptor (EGFR) were developed and characterized. Human epidermal growth factor (hEGF) and antibody-like protein Z1907 were used as a ligand module. We demonstrated that MNTs are able to internalize in a receptor-specific manner into the target cancer cells and to accumulate in the target cell nuclei. Conjugation of MNTs with the Auger electron emitter 111In significantly enhanced the cytotoxic effect of 111In on the target cells. It was found that the transfer of EGF from the C-terminus to the N-terminus of the MNT enhanced the proliferation of target cells, whereas the use of Z1907 did not have a similar effect. |
| تدمد: | 1608-3091 1607-6729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59598fb1151c6411dda5731f3ff1a51d https://doi.org/10.1134/s1607672920010081 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....59598fb1151c6411dda5731f3ff1a51d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16083091 16076729 |
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