Accelerated cognitive ageing in epilepsy: A neuropsychological evaluation of cognitive deterioration
| العنوان: | Accelerated cognitive ageing in epilepsy: A neuropsychological evaluation of cognitive deterioration |
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| المؤلفون: | Albert P. Aldenkamp, Evelien Carrette, Antoine Bernas, Lisanne E. M. Breuer, René M.H. Besseling, Anton J.A. de Louw, Paul Boon |
| المساهمون: | Video Coding & Architectures, Electromagnetics, Center for Care & Cure Technology Eindhoven, Signal Processing Systems, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen |
| المصدر: | Archives of Clinical Neuropsychology, 34(3), 301-309. Elsevier Archives of Clinical Neuropsychology, 34(3), 301-309. Elsevier BV |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Cognitive Aging/psychology, 050103 clinical psychology, Intelligence, Aptitude, wais-iii, Audiology, Neuropsychological Tests, SDG 3 – Goede gezondheid en welzijn, Epilepsy, Cognition, CONNECTIVITY, Medicine, Cognitive deterioration, media_common, 05 social sciences, Neuropsychology, Wechsler-Adult Intelligence Scale-Fourth Edition, Wechsler Adult Intelligence Scale, PREMORBID INTELLIGENCE, General Medicine, Middle Aged, NETWORKS, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Cognition Disorders/complications, Female, Cognitive ageing, Adult, medicine.medical_specialty, impairment, media_common.quotation_subject, brain, VALIDATION, Accelerated Cognitive Ageing, SDG 3 - Good Health and Well-being, Memory, Memory impairment, Humans, 0501 psychology and cognitive sciences, Epilepsy/complications, Aged, business.industry, General Ability Index, medicine.disease, eye diseases, stomatognathic diseases, Cognitive Aging, IQ, Cognition Disorders, business |
| الوصف: | Objective: Shed light on cognitive deterioration in Accelerated Cognitive Ageing (ACA) in epilepsy from a neuropsychological point of view in order to improve clinical diagnostics. Methods: We compared the IQ-profile including GAI, OPIE IV-premorbid IQ and deterioration-scores of 21 epilepsy patients with ACA with 21 matched epilepsy patients without ACA (Epilepsy Controls) and 16 age- and education-matched Healthy Controls. Memory was also evaluated. Results: Premorbid IQs were equal in all groups. Deterioration was apparent in the ACA-group in the WAIS-IV FSIQ and PRI, whereas no deterioration was found in the two control groups. PSI was impaired in both epilepsy groups, though with more impairment seen in the ACA-group. The VCI remained unimpaired. The FSIQ-GAI discrepancy was equal in both patient groups and significantly larger than in the Healthy Controls. WMS-IV memory indices were of average level in all groups. Memory impairment in ACA was not statistically different from the Epilepsy Controls. 85.7% of ACA-patients could be correctly classified through factors DET_FSIQ and PSI. Conclusions: Cognitive deterioration in ACA is characterized by an average drop of 19 IQ-points in FSIQ and PRI. Verbal abilities remain unimpaired. Impairments in fluid functions compromise cognitive abilities in epilepsy, but only partially contribute to cognitive deterioration in ACA. PSI proved to have some diagnostic value in differentiating epilepsy patients from healthy controls, but fails to differentiate between ACA and Epilepsy Controls. A comparison made between OPIE-IV equations and obtained IQs leads to a significant better detection of cognitive deterioration in epilepsy than the use of GAI-FSIQ discrepancies alone. |
| اللغة: | English |
| تدمد: | 0887-6177 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595e6d119e0960235592d474404ba180 https://research.tue.nl/nl/publications/0398292a-9834-48d7-839e-3005a73a80bc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....595e6d119e0960235592d474404ba180 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08876177 |
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