Bridging thrombolysis improves survival rates at 90 days compared with direct mechanical thrombectomy alone in acute ischemic stroke due to basilar artery occlusion: a systematic review and meta-analysis of 1096 patients
| العنوان: | Bridging thrombolysis improves survival rates at 90 days compared with direct mechanical thrombectomy alone in acute ischemic stroke due to basilar artery occlusion: a systematic review and meta-analysis of 1096 patients |
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| المؤلفون: | Keng Siang Lee, Isabel Siow, John JY Zhang, Nicholas L Syn, Conor S Gillespie, Linus ZH Yuen, Gopinathan Anil, Cunli Yang, Bernard PL Chan, Vijay Kumar Sharma, Hock-Luen Teoh, Jing Mingxue, Kevin Soon Hwee Teo, May Zin Myint, Pervinder Bhogal, Lukas Meyer, Stefan Schob, Ching-Hui Sia, Anastasios Mpotsaris, Volker Maus, Tommy Andersson, Fabian Arnberg, Vamsi Krishna Gontu, Tsong-Hai Lee, Benjamin Y Q Tan, Leonard LL Yeo |
| المصدر: | Journal of NeuroInterventional Surgery. :jnis-2022 |
| بيانات النشر: | BMJ, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Surgery, Neurology (clinical), General Medicine |
| الوصف: | BackgroundMechanical thrombectomy (MT) is an effective treatment for patients with acute ischemic stroke (AIS) from basilar artery occlusion (BAO).ObjectiveTo compare the clinical outcomes of MT, with and without bridging intravenous thrombolysis (IVT), in acute BAO through a systematic review and meta-analysis of the current literature.MethodsSystematic searches of Medline, EMBASE, and Cochrane Central were undertaken on August 1, 2022. Good functional outcome defined as 90-day modified Rankin Scale score 0–2 was the primary outcome measure. Secondary outcome measures were 90-day mortality, successful post-thrombectomy recanalization (modified Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracranial hemorrhage (sICH), and subarachnoid hemorrhage (SAH).ResultsThree studies reporting 1096 patients with BAO AIS were included in the meta-analysis. No significant differences in good functional outcome were detected between the two groups (RR=1.28 (95% CI 0.86 to 1.92); p=0.117). However, specifically patients with large artery atherosclerosis (LAA) benefited from bridging IVT (OR=2.52 (95% CI 1.51 to 4.22); pConclusionsIn patients with AIS due to BAO, bridging IVT was associated with lower mortality rates at 90 days, compared with direct MT. There were no improved functional outcomes or increased sICH or SAH between both arms, However, patients with LAA benefited from bridging IVT, with better functional outcomes. |
| تدمد: | 1759-8486 1759-8478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d689c803bb140f3c075e6c122e2700 https://doi.org/10.1136/jnis-2022-019510 |
| رقم الأكسشن: | edsair.doi.dedup.....59d689c803bb140f3c075e6c122e2700 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17598486 17598478 |
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