Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC)
| العنوان: | Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC) |
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| المؤلفون: | Olivia Sgarbura, Clarisse Eveno, Mohammad Alyami, Naoual Bakrin, Delia Cortes Guiral, Wim Ceelen, Xavier Delgadillo, Thanh Dellinger, Andrea Di Giorgio, Amaniel Kefleyesus, Vladimir Khomiakov, Michael Bau Mortensen, Jamie Murphy, Marc Pocard, Marc Reymond, Manuela Robella, Koen P. Rovers, Jimmy So, S.P. Somashekhar, Clemens Tempfer, Kurt Van der Speeten, Laurent Villeneuve, Wei Peng Yong, Martin Hübner |
| المصدر: | Pleura and peritoneum, vol. 7, no. 1, pp. 1-7 Sgarbura, O, Eveno, C, Alyami, M, Bakrin, N, Guiral, D C, Ceelen, W, Delgadillo, X, Dellinger, T, Di Giorgio, A, Kefleyesus, A, Khomiakov, V, Mortensen, M B, Murphy, J, Pocard, M, Reymond, M, Robella, M, Rovers, K P, So, J, Somashekhar, S P, Tempfer, C, Van Der Speeten, K, Villeneuve, L, Yong, W P & Hübner, M 2022, ' Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC) ', Pleura and Peritoneum, vol. 7, no. 1, pp. 1-7 . https://doi.org/10.1515/pp-2022-0102 PLEURA AND PERITONEUM |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | HIPEC, ENHANCED RECOVERY, treatment protocol, cisplatindoxorubicinoxaliplatinperitoneal metastasisPIPACstandardisationtreatment protocol, PIPAC, cisplatin, doxorubicin, oxaliplatin, peritoneal metastasis, standardisation, RATIONALE, CYTOREDUCTIVE SURGERY CRS, GUIDELINES, PERITONEAL METASTASES, ERAS(R) SOCIETY RECOMMENDATIONS, Medicine and Health Sciences, Internal Medicine, PERIOPERATIVE CARE |
| الوصف: | Objectives Safe implementation and thorough evaluation of new treatments require prospective data monitoring and standardization of treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment of patients with peritoneal disease with an increasing number of suggested drug regimens. The aim was to reach expert consensus on current PIPAC treatment protocols and to define the most important research topics. Methods The expert panel included the most active PIPAC centers, organizers of PIPAC courses and principal investigators of prospective studies on PIPAC. A comprehensive literature review served as base for a two-day hybrid consensus meeting which was accompanied by a modified three-round Delphi process. Consensus bar was set at 70% for combined (strong and weak) positive or negative votes according to GRADE. Research questions were prioritized from 0 to 10 (highest importance). Results Twenty-two out of 26 invited experts completed the entire consensus process. Consensus was reached for 10/10 final questions. The combination of doxorubicin (2.1 mg/m2) and cisplatin (10.5 mg/m2) was endorsed by 20/22 experts (90.9%). 16/22 (72.7%) supported oxaliplatin at 120 with potential reduction to 90 mg/m2 (frail patients), and 77.2% suggested PIPAC-Ox in combination with 5-FU. Mitomycin-C and Nab-paclitaxel were favoured as alternative regimens. The most important research questions concerned PIPAC conditions (n=3), standard (n=4) and alternative regimens (n=5) and efficacy of PIPAC treatment (n=2); 8/14 were given a priority of ≥8/10. Conclusions The current consensus should help to limit heterogeneity of treatment protocols but underlines the utmost importance of further research. |
| وصف الملف: | application/pdf |
| تدمد: | 2364-768X 2364-7671 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d7ff2e3b269fb423072fa1d8999be6 https://pubmed.ncbi.nlm.nih.gov/35602919 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....59d7ff2e3b269fb423072fa1d8999be6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2364768X 23647671 |
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