The SOS Pilot Study: A RCT of Routine Oxygen Supplementation Early after Acute Stroke—Effect on Recovery of Neurological Function at One Week
| العنوان: | The SOS Pilot Study: A RCT of Routine Oxygen Supplementation Early after Acute Stroke—Effect on Recovery of Neurological Function at One Week |
|---|---|
| المؤلفون: | Sheila Sills, Anushka Warusevitane, Peter W. Jones, Frank Lally, Christine Roffe, Peter Crome, Sarah Pountain, John Hodsoll, Martin W. Allen, Khalid Ali |
| المصدر: | PLoS ONE PLoS ONE, Vol 6, Iss 5, p e19113 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Critical Care and Emergency Medicine, Time Factors, Pilot Projects, Brain Ischemia, law.invention, Brain ischemia, Clinical trials, Randomized controlled trial, Interquartile range, law, Nervous System Physiological Phenomena, Single-Blind Method, Oximetry, Hypoxia, Stroke, Multidisciplinary, Oxygen supplementation, Phase II, Hospitalization, Hemorrhagic Stroke, Treatment Outcome, Neurology, Neurointensive Care, Anesthesia, Medicine, Female, medicine.symptom, Research Article, medicine.medical_specialty, Science, Cerebrovascular Diseases, Neurorehabilitation and Trauma, medicine, Transient Ischemic Attacks, Humans, Ischemic Stroke, Aged, Acute stroke, business.industry, Oxygen Inhalation Therapy, Recovery of Function, Hypoxia (medical), medicine.disease, R1, Oxygen, Clinical trial, Physical therapy, Clinical research design, business, RC |
| الوصف: | UnlabelledMild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12 months. This pilot study reports the effects of routine oxygen supplementation for 72 hours on oxygen saturation and neurological outcomes at 1 week after a stroke.MethodsPatients with a clinical diagnosis of acute stroke were recruited within 24 h of hospital admission between October 2004 and April 2008. Participants were randomized to oxygen via nasal cannulae (72 h) or control (room air, oxygen given only if clinically indicated). Clinical outcomes were assessed by research team members at 1 week. Baseline data for oxygen (n = 148) and control (n = 141) did not differ between groups.ResultsThe median (interquartile range) National Institutes of Health Stroke Scale (NIHSS) score for the groups at baseline was 6 (7) and 5 (7) respectively. The median Nocturnal Oxygen Saturation during treatment was 1.4% (0.3) higher in the oxygen than in the control group (pConclusionOur data show that routine oxygen supplementation started within 24 hours of hospital admission with acute stroke led to a small, but statistically significant, improvement in neurological recovery at 1 week. However, the difference in NIHSS improvement may be due to baseline imbalance in stroke severity between the two groups and needs to be confirmed in a larger study and linked to longer-term clinical outcome.Trial registrationControlled-Trials.com ISRCTN12362720; European Clinical Trials Database 2004-001866-41. |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 1549-1277 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e980b401d1a926a14d935d8c0773f6 https://doi.org/10.1371/journal.pone.0019113 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....59e980b401d1a926a14d935d8c0773f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 15491277 |
|---|