Dual functions of epigallocatechin gallate surface-modified Au nanorods@selenium composites for near-infrared-II light-responsive synergistic antibacterial therapy
| العنوان: | Dual functions of epigallocatechin gallate surface-modified Au nanorods@selenium composites for near-infrared-II light-responsive synergistic antibacterial therapy |
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| المؤلفون: | Bingbing wu, Yuyan Shao, Wei Zhao, Yunfang Zheng, yunsheng Wang, Dongdong Sun |
| المصدر: | Journal of Biomaterials Applications. 36:1812-1825 |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Biomaterials, Mice, Selenium, Staphylococcus aureus, Nanotubes, Biomedical Engineering, Animals, Gold, Catechin, Anti-Bacterial Agents |
| الوصف: | Diseases caused by bacterial infections pose ever-increasing threats to human health, making it important to explore alternative antibacterial strategies. Herein, epigallocatechin gallate (EGCG) surface-modified Au nanorods@selenium composites (ASE NPs) were developed for synergistic NIR-II light-responsive antibacterial therapy. In vitro antibacterial experiments demonstrated the improved antibacterial effect of ASE NPs against Staphylococcus aureus ( S. aureus) compared with EGCG alone. In addition, in vivo studies demonstrated that ASE NPs cured skin wound infections and sepsis in mice caused by S. aureus. Au nanorods with excellent photothermal conversion realized synergistic photothermal therapy (PTT) in the NIR-II biowindow with an improved penetration depth at a low power density. More importantly, toxicity analysis showed that the composites had no toxic effects on major organs. Thus, the EGCG surface-modified Au nanorods@selenium composites with an NIR-II light-responsive synergistic activity hold great promise for the effective treatment of drug-resistant bacterial infections. |
| تدمد: | 1530-8022 0885-3282 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0398d22725a63f7143015a0e4be09a https://doi.org/10.1177/08853282211048570 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5a0398d22725a63f7143015a0e4be09a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308022 08853282 |
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