Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
| العنوان: | Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome |
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| المؤلفون: | Chen Yu Shiao, Chien-Yeh Hsu, Chian Sem Chua, Kuo Ching Yang, Chyi Huey Bai, Chiao Wen Cheng, Jung-Lung Hsu, Hung Wen Chiu |
| المصدر: | PLoS ONE, Vol 12, Iss 8, p e0183960 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Central Nervous System, Abdominal pain, Physiology, Sensory Physiology, lcsh:Medicine, Pathology and Laboratory Medicine, Nervous System, Severity of Illness Index, Gastroenterology, Diagnostic Radiology, Irritable Bowel Syndrome, 0302 clinical medicine, Cortex (anatomy), Medicine and Health Sciences, lcsh:Science, Irritable bowel syndrome, Depression (differential diagnoses), Cerebral Cortex, Brain Mapping, Multidisciplinary, medicine.diagnostic_test, Depression, Radiology and Imaging, Brain, Middle Aged, Magnetic Resonance Imaging, Sensory Systems, Frontal Lobe, medicine.anatomical_structure, Somatosensory System, Frontal lobe, Female, 030211 gastroenterology & hepatology, Occipital Lobe, Anatomy, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Imaging Techniques, Pain, Prefrontal Cortex, Neuroimaging, Research and Analysis Methods, Gyrus Cinguli, 03 medical and health sciences, Signs and Symptoms, Asian People, Diagnostic Medicine, Internal medicine, Mental Health and Psychiatry, Image Interpretation, Computer-Assisted, medicine, Humans, Anterior cingulate cortex, Mood Disorders, business.industry, lcsh:R, Biology and Life Sciences, Pain Sensation, Magnetic resonance imaging, medicine.disease, Abdominal Pain, Case-Control Studies, lcsh:Q, business, Insula, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Background & aims Irritable bowel syndrome (IBS) manifests as chronic abdominal pain. One pathophysiological theory states that the brain–gut axis is responsible for pain control in the intestine. Although several studies have discussed the structural changes in the brain of IBS patients, most of these studies have been conducted in Western populations. Different cultures and sexes experience different pain sensations and have different pain responses. Accordingly, we aimed to identify the specific changes in the cortical thickness of Asian women with IBS and to compare these data to those of non-Asian women with IBS. Methods Thirty Asian female IBS patients (IBS group) and 39 healthy individuals (control group) were included in this study. Brain structural magnetic resonance imaging was performed. We used FreeSurfer to analyze the differences in the cortical thickness and their correlations with patient characteristics. Results The left cuneus, left rostral middle frontal cortex, left supramarginal cortex, right caudal anterior cingulate cortex, and bilateral insula exhibited cortical thinning in the IBS group compared with those in the controls. Furthermore, the brain cortical thickness correlated negatively the severity as well as duration of abdominal pain. Conclusions Some of our findings differ from those of Western studies. In our study, all of the significant brain regions in the IBS group exhibited cortical thinning compared with those in the controls. The differences in cortical thickness between the IBS patients and controls may provide useful information to facilitate regulating abdominal pain in IBS patients. These findings offer insights into the association of different cultures and sexes with differences in cortical thinning in patients with IBS. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a568f0a923c550d8fb3f63f8388fda5 http://europepmc.org/articles/PMC5578615?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5a568f0a923c550d8fb3f63f8388fda5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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