Clinical onset of multiple sclerosis (MSComparing the clinical characteristics of MSConsecutive patients with clinical onset ≤30 days after SARS-CoV-2-vaccination were included. Clinical data, cerebrospinal fluid (CSF) parameters and magnetic resonance imaging (MRI) as well as optical coherence tomography (OCT) data were compared to an age- and sex-matched MSWe identified 5 MSOur case series indicates that MS