The Nature of EEG Reactivity to Light, Sound, and Pain Stimulation in Neurosurgical Comatose Patients Evaluated by a Quantitative Method
| العنوان: | The Nature of EEG Reactivity to Light, Sound, and Pain Stimulation in Neurosurgical Comatose Patients Evaluated by a Quantitative Method |
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| المؤلفون: | Birger Johnsen, Kristoffer B Nøhr, Christophe Henri Valdemar Duez, Mads Qvist Ebbesen |
| المصدر: | Johnsen, B, Backman Nøhr, K, Duez, C H V & Ebbesen, M Q 2017, ' The Nature of EEG reactivity to light, sound and pain stimulation in neurosurgical comatose patients evaluated by a quantitative method ', Clinical E E G and Neuroscience, vol. 48, no. 6, pp. 428-437 . https://doi.org/10.1177/1550059417726475 |
| بيانات النشر: | SAGE Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Light, Pain, Alpha (ethology), Stimulation, Electroencephalography, 03 medical and health sciences, Beta band, 0302 clinical medicine, medicine, Humans, Coma, Reactivity (psychology), Aged, Aged, 80 and over, medicine.diagnostic_test, Glasgow Outcome Scale, Brain, 030208 emergency & critical care medicine, General Medicine, Middle Aged, Prognosis, Sound, Neurology, Eeg activity, Anesthesia, Female, Neurology (clinical), medicine.symptom, Psychology, 030217 neurology & neurosurgery |
| الوصف: | EEG reactivity (EEG-R) is regarded as an important parameter in coma prognosis but knowledge is sparse on the nature of EEG changes due to different kinds of stimulation and their prognostic significance. EEG-R was quantified in a study of 39 comatose neurosurgical patients. Six 30-second standardized visual, auditory, and painful stimulations were applied. EEG-R in the delta, theta, alpha, and beta band was normalized in z-scores as the power of a stimulation epoch relative to average power of 6 resting epochs. Outcome measure was 3 months Glasgow Outcome Scale. Increase in EEG activity was related to poor outcome, was more common (13.4% of tests), and grew continuously during the 30-second stimulation epoch. Decrease in EEG activity was related to good outcome, was rarer (2.5%), and peaked around 15 seconds. Pain was the most provocative stimulation (20.4%) followed by sound (8.7%) and eye-opening (6.7%). Discrimination between good (n = 6) and poor (n = 33) outcome was best in the theta and alpha bands for pain stimulation in the first 10-20 seconds and for sound stimulation in the first 5 to 10 seconds, eye-opening did not discriminate. Increase in activity predicted poor outcome with a high specificity 100% (CI = 52%-100%) and a modest sensitivity of 39% (CI = 23%-58%). Decrease in activity predicted good outcome with a high specificity of 100% (CI = 87%-100%) and a modest sensitivity of 33% (CI = 6%-76%). This quantitative study reveals new knowledge about the nature of EEG-R, which contribute to the development of more reliable and objective clinical procedures for outcome prediction. |
| تدمد: | 2169-5202 1550-0594 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aab63fedd05baff98b7c6f5e1aacce3 https://doi.org/10.1177/1550059417726475 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....5aab63fedd05baff98b7c6f5e1aacce3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21695202 15500594 |
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