The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth
| العنوان: | The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth |
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| المؤلفون: | Hirotaka Nishi, Mei-Lu Bian, Jing Liang, Hiroe Ito, Chinatsu Higuma, Toru Sasaki, Keiichi Isaka |
| المصدر: | Oncology Reports. 28:1519-1525 |
| بيانات النشر: | Spandidos Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cancer Research, Paclitaxel, Topoisomerase Inhibitors, Mice, Nude, Uterine Cervical Neoplasms, Biology, medicine.disease_cause, Mice, Reference Values, Cell Line, Tumor, medicine, Animals, Humans, RNA, Small Interfering, Promoter Regions, Genetic, Etoposide, Cell Proliferation, Cervical cancer, Gene knockdown, Oncogene, Cancer, General Medicine, Cell cycle, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Gene Expression Regulation, Neoplastic, Oncology, Doxorubicin, Gene Knockdown Techniques, Ubiquitin-Conjugating Enzymes, Carcinoma, Squamous Cell, Cancer research, Female, Topotecan, Topoisomerase I Inhibitors, Carcinogenesis, medicine.drug |
| الوصف: | We found that the ubiquitin-conjugating enzyme E2-EPF mRNA is highly expressed in cervical squamous cancer relative to normal tissues and its expression levels positively correlate with clinical stage. Reduction of E2-EPF protein levels by >80% using shRNA decreases the expression levels of HIF-1α, and the proliferation, invasion and tumorigenicity of SiHa, a cervical squamous cancer cell line. E2-EPF knockdown also increases the chemosensitivity to topoisomerase I inhibitor (topotecan) and II (etoposide and doxorubicin). Our results suggest that E2-EPF is associated with the growth and aggressivity of cervical tumor cells. Targeting the E2-EPF pathway may have potential clinical applications for the treatment of cervical cancer. |
| تدمد: | 1791-2431 1021-335X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac675516234f105fd9f4ad1ab3aecbb https://doi.org/10.3892/or.2012.1949 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5ac675516234f105fd9f4ad1ab3aecbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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