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Viral genotype-specific role of PNPLA3 , PPARG , MTTP, and IL28B in hepatitis C virus-associated steatosis

التفاصيل البيبلوغرافية
العنوان: Viral genotype-specific role of PNPLA3 , PPARG , MTTP, and IL28B in hepatitis C virus-associated steatosis
المؤلفون: Pierre-Yves Bochud, Tilman Gerlach, Tao Cai, Beat Muellhaupt, Francesco Negro, Jean-François Dufour, Darius Moradpour, Murielle Bochud, V. Kaddai, Andreas Cerny, Raffaele Malinverni, Markus H. Heim
المصدر: Journal of Hepatology, Vol. 55, No 3 (2011) pp. 529-35
Journal of hepatology
بيانات النشر: Elsevier BV, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Male, Carrier Proteins/genetics, Hepatitis C, Chronic/complications/virology, Hepacivirus, ddc:616.07, medicine.disease_cause, Severity of Illness Index, 0302 clinical medicine, Interleukins/genetics, Genotype, ddc:616, 0303 health sciences, biology, Fatty liver, PPAR gamma/genetics, Hepatitis C, Middle Aged, Fatty Liver/complications/genetics/virology, 3. Good health, Female, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, Hepatitis C virus, Hepacivirus/genetics, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, medicine, Humans, Membrane Proteins/genetics, 030304 developmental biology, Hepatology, Interleukins, Membrane Proteins, Lipase, Hepatitis C, Chronic, medicine.disease, biology.organism_classification, Virology, Fatty Liver, PPAR gamma, Logistic Models, Interleukin 28B, Endocrinology, Interferons, Steatosis, Carrier Proteins, Lipase/genetics, TCF7L2
الوصف: BACKGROUND 38; AIMS Steatosis is a prominent feature of hepatitis C especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size and important single nucleotide polymorphisms (SNPs) such as those in the patatin like phospholipase family 3 protein (PNPLA3) were never evaluated. METHODS We analyzed the role of SNPs from 19 systematically selected candidate genes on steatosis in 626 Caucasian hepatitis C virus (HCV) infected patients. SNPs were extracted from a genome wide association generated dataset. Associations of alleles with the presence and/or different severity of steatosis were evaluated by univariate and multivariate logistic regression accounting for all relevant covariates. RESULTS The risk of steatosis was increased by carriage of I148M in PNPLA3 but only in patients with HCV genotypes non 3 (odds ratio [OR]=1.9 95 confidence interval [CI]=1.6 2.3 p
تدمد: 0168-8278
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1b626c0cb38f7da382124d788278d5
https://doi.org/10.1016/j.jhep.2010.12.020
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....5b1b626c0cb38f7da382124d788278d5
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01688278