One ring to bind them – Cohesin’s interaction with chromatin fibers
| العنوان: | One ring to bind them – Cohesin’s interaction with chromatin fibers |
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| المؤلفون: | Macarena Moronta-Gines, Thomas van Staveren, Kerstin S. Wendt |
| المصدر: | Essays in Biochemistry. 63:167-176 |
| بيانات النشر: | Portland Press Ltd., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Multiprotein complex, Cohesin complex, Chromosomal Proteins, Non-Histone, Cell Cycle Proteins, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Yeasts, Animals, Humans, Molecular Biology, 030304 developmental biology, Chromatin Fiber, 0303 health sciences, biology, Cohesin, Chemistry, Chromatin binding, DNA, Plants, Chromatin, Cell biology, Histone, CTCF, biology.protein, biological phenomena, cell phenomena, and immunity, 030217 neurology & neurosurgery, Protein Binding |
| الوصف: | In the nuclei of eukaryotic cells, the genetic information is organized at several levels. First, the DNA is wound around the histone proteins, to form a structure termed as chromatin fiber. This fiber is then arranged into chromatin loops that can cluster together and form higher order structures. This packaging of chromatin provides on one side compaction but also functional compartmentalization. The cohesin complex is a multifunctional ring-shaped multiprotein complex that organizes the chromatin fiber to establish functional domains important for transcriptional regulation, help with DNA damage repair, and ascertain stable inheritance of the genome during cell division. Our current model for cohesin function suggests that cohesin tethers chromatin strands by topologically entrapping them within its ring. To achieve this, cohesin’s association with chromatin needs to be very precisely regulated in timing and position on the chromatin strand. Here we will review the current insight in when and where cohesin associates with chromatin and which factors regulate this. Further, we will discuss the latest insights into where and how the cohesin ring opens to embrace chromatin and also the current knowledge about the ‘exit gates’ when cohesin is released from chromatin. |
| تدمد: | 1744-1358 0071-1365 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b62b3d1b823090a129b22603d8758e5 https://doi.org/10.1042/ebc20180064 |
| رقم الأكسشن: | edsair.doi.dedup.....5b62b3d1b823090a129b22603d8758e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17441358 00711365 |
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