Toward prediction of abscopal effect in radioimmunotherapy: Pre-clinical investigation
| العنوان: | Toward prediction of abscopal effect in radioimmunotherapy: Pre-clinical investigation |
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| المؤلفون: | Ivaylo B. Mihaylov, Dazhi Wang, B. Spieler, Tulasigeri M. Totiger, Scott M. Welford, Teresa M. Giret |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 8, p e0255923 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Physiology, medicine.medical_treatment, Cancer Treatment, Blood count, Lung and Intrathoracic Tumors, Diagnostic Radiology, Mice, Clinical investigation, Medicine and Health Sciences, Medicine, Tomography, Multidisciplinary, medicine.diagnostic_test, Radiology and Imaging, Abscopal effect, Magnetic Resonance Imaging, Combined Modality Therapy, Body Fluids, Blood, Oncology, Radioimmunotherapy, Immunotherapy, Anatomy, Research Article, Clinical Oncology, Imaging Techniques, Science, Radiation Therapy, Neuroimaging, Research and Analysis Methods, Diagnostic Medicine, Cell Line, Tumor, Animals, Humans, business.industry, Cancers and Neoplasms, Biology and Life Sciences, Lewis lung carcinoma, Magnetic resonance imaging, Computed Axial Tomography, Non-Small Cell Lung Cancer, Blood Counts, Radiation therapy, Regimen, Radiation Oncology, Clinical Medicine, Nuclear medicine, business, Neuroscience |
| الوصف: | Purpose Immunotherapy (IT) and radiotherapy (RT) can act synergistically, enhancing antitumor response beyond what either treatment can achieve separately. Anecdotal reports suggest that these results are in part due to the induction of an abscopal effect on non-irradiated lesions. Systematic data on incidence of the abscopal effect are scarce, while the existence and the identification of predictive signatures or this phenomenon are lacking. The purpose of this pre-clinical investigational work is to shed more light on the subject by identifying several imaging features and blood counts, which can be utilized to build a predictive binary logistic model. Materials and methods This proof-of-principle study was performed on Lewis Lung Carcinoma in a syngeneic, subcutaneous murine model. Nineteen mice were used: four as control and the rest were subjected to combined RT plus IT regimen. Tumors were implanted on both flanks and after reaching volume of ~200 mm3 the animals were CT and MRI imaged and blood was collected. Quantitative imaging features (radiomics) were extracted for both flanks. Subsequently, the treated animals received radiation (only to the right flank) in three 8 Gy fractions followed by PD-1 inhibitor administrations. Tumor volumes were followed and animals exhibiting identical of better tumor growth delay on the non-irradiated (left) flank as compared to the irradiated flank were identified as experiencing an abscopal effect. Binary logistic regression analysis was performed to create models for CT and MRI radiomics and blood counts, which are predictive of the abscopal effect. Results Four of the treated animals experienced an abscopal effect. Three CT and two MRI radiomics features together with the pre-treatment neutrophil-to-lymphocyte (NLR) ratio correlated with the abscopal effect. Predictive models were created by combining the radiomics with NLR. ROC analyses indicated that the CT model had AUC of 0.846, while the MRI model had AUC of 0.946. Conclusions The combination of CT and MRI radiomics with blood counts resulted in models with AUCs of 1 on the modeling dataset. Application of the models to the validation dataset exhibited AUCs above 0.84, indicating very good predictive power of the combination between quantitative imaging and blood counts. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7f122d543b3ebbd6272edd27bfb6df https://doi.org/10.1371/journal.pone.0255923 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5b7f122d543b3ebbd6272edd27bfb6df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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