Intranasal immunization with inactivated feline calicivirus particles confers robust protection against homologous virus and suppression against heterologous virus in cats
| العنوان: | Intranasal immunization with inactivated feline calicivirus particles confers robust protection against homologous virus and suppression against heterologous virus in cats |
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| المؤلفون: | Kayo Iwamoto, Eiji Oishi, Risa Kainuma, Hiroaki Sato, Nobutaka Okada, Go Sehata, Takuo Sawada, Katsuo Masubuchi, Tatsuki Noda, Tatsuhiko Igarashi, Taichi Noro |
| المصدر: | Journal of General Virology. 98:1730-1738 |
| بيانات النشر: | Microbiology Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, 040301 veterinary sciences, Heterologous, Antibodies, Viral, Cat Diseases, Virus, 0403 veterinary science, 03 medical and health sciences, Immunity, Virology, Animals, Viral shedding, Neutralizing antibody, Administration, Intranasal, Caliciviridae Infections, Feline calicivirus, CATS, biology, Vaccination, Viral Vaccines, 04 agricultural and veterinary sciences, biology.organism_classification, Antibodies, Neutralizing, Immunoglobulin A, 030104 developmental biology, Vaccines, Inactivated, Immunization, Cats, biology.protein, Calicivirus, Feline |
| الوصف: | The protective efficacy of intranasal (IN) administration of inactivated feline calicivirus (FCV) vaccine against homologous or heterologous FCV infection was investigated. Groups of cats immunized with the experimental inactivated, non-adjuvanted FCV vaccine via either the IN or subcutaneous (SC) route were exposed to homologous or highly heterologous FCV. Both the IN and SC immunization protocols established robust protection against homologous FCV infection. Although neither immunization regimen conferred protection against the heterologous strain, clinical scores and virus titres of oral swabs were lower in cats in the IN group compared to those in the SC group, accompanying a faster neutralizing antibody response against the heterologous virus in cats in the IN group. The IN group secreted more IgA specific to FCV proteins in oral washes (lavage fluids from the oral cavity) than the SC group. IN immunization with an inactivated whole FCV particle, which protects cats from homologous virus exposure and shortens the period of heterologous virus shedding, may serve as a better platform for anti-FCV vaccine. |
| تدمد: | 1465-2099 0022-1317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b878adf2c35df8bc0fd74ae9a2afba1 https://doi.org/10.1099/jgv.0.000827 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5b878adf2c35df8bc0fd74ae9a2afba1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14652099 00221317 |
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