Summary Teflon tubes containing freshly mixed, polymerized Hydron root canal filling material, folly set AH26 or Teflon were implanted into the mandible of guinea pigs andassessedhiilogically at 2 days. l,2,4,12 and 26 weeks. None of the materials tested elicited signs of overt or significant tissue damage, and polymerized Hydron was assessd to be as biocompatible as folly set AH26 and Teflon. Bone formed in very close apposition to the polymerized Hydron. whereas a soft tissue capsule separated the regenerated bone loom implants of AH26 and Teflon.