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Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants

التفاصيل البيبلوغرافية
العنوان: Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants
المؤلفون: Amelia M. Brown, Illya Conn, Danny Boerrigter, Cynthia Shannon Weickert, Tertia D. Purves-Tyson
المصدر: Journal of Neuroimmunology. 364:577813
بيانات النشر: Elsevier BV, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Male, Immunology, Monocyte Chemoattractant Proteins, Rats, Disease Models, Animal, Poly I-C, Neurology, Neurodevelopmental Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Animals, Cytokines, Immunology and Allergy, Female, Neurology (clinical), Pregnancy Complications, Infectious, Rats, Wistar
الوصف: Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We established in Wistar rats that 4 mg/kg high molecular weight (HMW)-poly(I:C) on GD19 induces maternal sickness, smaller litters and maternal elevations of serum cytokines, including increases in monocyte chemoattractants. In adult offspring, we found that males have higher serum cytokines than females, and MIA did not alter peripheral cytokines in either sex. Our study will contribute to the effective use of the MIA model to elucidate the neurobiology of neurodevelopmental disorders.
تدمد: 0165-5728
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba50b93797be6135b153a11a73eb859
https://doi.org/10.1016/j.jneuroim.2022.577813
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....5ba50b93797be6135b153a11a73eb859
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01655728