Changes in connexin 43 in inflammatory skin disorders: Eczema, psoriasis, and Steven‐Johnson syndrome/toxic epidermal necrolysis
| العنوان: | Changes in connexin 43 in inflammatory skin disorders: Eczema, psoriasis, and |
|---|---|
| المؤلفون: | Hui L. Kwong, David L. Becker, Joyce Siong See Lee, Mandy Li Ling Tan, Chia C. Ang, Hong L. Tey |
| المصدر: | Health Science Reports, Vol 4, Iss 1, Pp n/a-n/a (2021) Health Science Reports |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, psoriasiform, Connexin, Inflammation, gap junction, Psoriasis, Medicine, Research Articles, dermatitis, integumentary system, business.industry, epidermal necrosis, General Medicine, medicine.disease, Toxic epidermal necrolysis, Staining, expression patterns, Epidermal necrosis, cardiovascular system, sense organs, biological phenomena, cell phenomena, and immunity, medicine.symptom, business, Wound healing, Research Article, Spongiosis |
| الوصف: | Background Connexin 43 (Cx43) plays a central role in the inflammatory response and wound healing. Targeting Cx43 expression reduces inflammation in a variety of injuries. The expression pattern of Cx43 has not been described for many inflammatory skin diseases. Objectives To describe the expression patterns of Cx43 in eczema, psoriasis, Steven‐Johnson syndrome/toxic epidermal necrolysis. Methods Archival skin biopsies from patients with eczema, psoriasis, and Steven‐Johnson syndrome/toxic epidermal necrosis were identified and examined, with sister sections stained for Cx43 and imaged by confocal microscopy. All samples were compared to age and site‐matched normal skin controls. Results Epidermal Cx43 is reduced in acute eczema, absent in regions of spongiosis, and is highly elevated in subacute and chronic eczema. In plaque psoriasis, Cx43 is overexpressed in areas with psoriasiform hyperplasia with a fish‐scale‐like appearance but is lost in regions surrounding neutrophil microabscesses. Cx43 staining is strong in the neutrophils within these microabscesses. In SJS/TEN, Cx43 expression is elevated in areas bordering normal tissue but is rapidly lost in areas of keratinocyte necrosis. Conclusions Dynamic changes in Cx43 levels are seen in inflammatory skin diseases and may represent future potential therapeutic targets. Connexin 43 (Cx43) plays a central role in the inflammatory response and wound healing. Targeting Cx43 expression reduces inflammation in a variety of injuries. Here we examine the changes in Cx43 protein levels in the epidermis in eczema, psoriasis, Steven‐Johnson Syndrome/Toxic Epidermal necrolysis. |
| تدمد: | 2398-8835 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc9d05f81b2a0c08bee997e8e7783e8 https://doi.org/10.1002/hsr2.247 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5bc9d05f81b2a0c08bee997e8e7783e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23988835 |
|---|