Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis
| العنوان: | Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis |
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| المؤلفون: | Adam Shellard, András Szabó, Xavier Trepat, Roberto Mayor |
| المصدر: | Science |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Xenopus, Population, 03 medical and health sciences, Neural Stem Cells, Animals, education, Zebrafish, Embryonic Stem Cells, Cell chemotaxis, education.field_of_study, Multidisciplinary, biology, Chemistry, Chemotaxis, Neural crest, Actomyosin, Zebrafish Proteins, biology.organism_classification, Embryonic stem cell, Chemokine CXCL12, Neural stem cell, Cell biology, Optogenetics, 030104 developmental biology, Neural Crest |
| الوصف: | Supracellular cable drives collective cell movement Neural crest cells migrate far and wide through a vertebrate embryo during development. Shellard et al. used Xenopus and zebrafish embryos to study how these clumps of mesenchymal cells migrate (see the Perspective by Adameyko). Movement was powered by a supracellular actomyosin cable that contracted around the rear of the clump. Similar supracellular contractility at the front was inhibited by a chemotactic signal. The imbalance in forces caused cells to rearrange so that the whole clump would be propelled forward. Science , this issue p. 339 ; see also p. 290 |
| تدمد: | 1095-9203 0036-8075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be31bf118894756471d33107d65155f https://doi.org/10.1126/science.aau3301 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5be31bf118894756471d33107d65155f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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