Endoscopic Perductal Electrolytic Ablation of the Pancreas: Experimental Studies of Morbidity and Mortality

التفاصيل البيبلوغرافية
العنوان: Endoscopic Perductal Electrolytic Ablation of the Pancreas: Experimental Studies of Morbidity and Mortality
المؤلفون: Matthew S. Metcalfe, C. P. Morrison, B. D. Teague, Michael Texler, Guy J. Maddern, Simon A. Wemyss-Holden, F. G. Court, A.R. Dennison
المصدر: Digestive Diseases. 23:83-91
بيانات النشر: S. Karger AG, 2005.
سنة النشر: 2005
مصطلحات موضوعية: medicine.medical_specialty, Swine, medicine.medical_treatment, Electrolysis, Random Allocation, Pancreatic cancer, medicine, Animals, Pancreatic duct, Endoscopic retrograde cholangiopancreatography, medicine.diagnostic_test, business.industry, Carcinoma, Pancreatic Ducts, Gastroenterology, Stent, Endoscopy, General Medicine, medicine.disease, Ablation, Surgery, Pancreatic Neoplasms, Disease Models, Animal, Catheter, medicine.anatomical_structure, Acute pancreatitis, Female, Morbidity, Pancreas, business
الوصف: Background: Palliation of pancreatic cancer remains the only option for the majority of patients. Palliative techniques such as surgical bypass and endoscopic retrograde cholangiopancreatography (ERCP) with stenting are not ideal. The ‘ideal’ palliative technique would combine the efficacy of surgery with the minimal complications of an endoscopic procedure. Endoscopically delivered perductal electrolytic ablation of pancreatic lesions has the potential to meet these criteria. Methods: Fifteen pigs were used. The pancreatic duct was cannulated with an electrolysis catheter. Animals were randomised to either: controls, treatment 2-week survivor or treatment 8-week survivor. An electrolytic dose was administered to the treatment animals. Post-operatively, serum amylase and leucocyte count were assessed. Pancreata were histologically examined to detect evidence of acute pancreatitis. Results: Electrolysis was well tolerated. There was no difference in post-operative hyperamylasaemia and leucocyte count between the groups. Histological examination showed inflammation at the ablation site at 2 weeks, by 8 weeks this was replaced by scarring. Conclusion: The results of this study suggest that endoscopic perductal electrolytic ablation of the pancreas is feasible and safe. Biochemical and histological findings indicate self-limiting localised inflammation of the pancreas. This technique may have a role in the palliation of pancreatic cancer and warrants further investigation.
تدمد: 1421-9875
0257-2753
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c89c01306c5b4d98cc002f3b630dd63
https://doi.org/10.1159/000084730
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....5c89c01306c5b4d98cc002f3b630dd63
قاعدة البيانات: OpenAIRE