Crosstalk between Bone and Nerves within Bone
| العنوان: | Crosstalk between Bone and Nerves within Bone |
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| المؤلفون: | Ji Hua Chen, Wen Pin Qin, Min Juan Shen, Yu Xuan Ma, Jing Li, Li Na Niu, Qian Qian Wan, Zi Bin Zhang, Franklin R. Tay, Kai Jiao |
| المصدر: | Advanced Science Advanced Science, Vol 8, Iss 7, Pp n/a-n/a (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Stromal cell, General Chemical Engineering, Osteoporosis, Reviews, General Physics and Astronomy, Medicine (miscellaneous), Review, Osteoarthritis, Biochemistry, Genetics and Molecular Biology (miscellaneous), Bone and Bones, crosstalk, Bone remodeling, bioactive factors, Nerve Fibers, medicine, Humans, General Materials Science, nerve growth, lcsh:Science, business.industry, General Engineering, Mesenchymal Stem Cells, medicine.disease, peripheral nerves, Crosstalk (biology), medicine.anatomical_structure, lcsh:Q, Heterotopic ossification, Axon guidance, bone metabolism, Bone marrow, Bone Diseases, business, Signal Transduction |
| الوصف: | For the past two decades, the function of intrabony nerves on bone has been a subject of intense research, while the function of bone on intrabony nerves is still hidden in the corner. In the present review, the possible crosstalk between bone and intrabony peripheral nerves will be comprehensively analyzed. Peripheral nerves participate in bone development and repair via a host of signals generated through the secretion of neurotransmitters, neuropeptides, axon guidance factors and neurotrophins, with additional contribution from nerve‐resident cells. In return, bone contributes to this microenvironmental rendezvous by housing the nerves within its internal milieu to provide mechanical support and a protective shelf. A large ensemble of chemical, mechanical, and electrical cues works in harmony with bone marrow stromal cells in the regulation of intrabony nerves. The crosstalk between bone and nerves is not limited to the physiological state, but also involved in various bone diseases including osteoporosis, osteoarthritis, heterotopic ossification, psychological stress‐related bone abnormalities, and bone related tumors. This crosstalk may be harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves. Some clues are given during biological processes as well as pathological disorders to allow the detection of the communication between bone and nerves within bone. The pattern of strings on the hand created by nature are intriguing and waiting for the wise play. |
| تدمد: | 2198-3844 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c96b2dbf45fe42dbdb72830c0116171 https://doi.org/10.1002/advs.202003390 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5c96b2dbf45fe42dbdb72830c0116171 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21983844 |
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