New secoiridoids from the fruits of Ligustrum lucidum
| العنوان: | New secoiridoids from the fruits of Ligustrum lucidum |
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| المؤلفون: | Zuo-cheng Qiu, Qing-Chang Wu, Man Sau Wong, Xiao-Xiao Zhao, Xin-Sheng Yao, Yi Dai, Jian-Wu Fu |
| المصدر: | Journal of Asian Natural Products Research. 20:431-438 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Dried fruit, Iridoid, medicine.drug_class, Stereochemistry, Ligustrum, Pharmaceutical Science, Cleavage (embryo), 01 natural sciences, Analytical Chemistry, Mice, Calcification, Physiologic, Osteogenesis, Drug Discovery, medicine, Animals, Iridoids, Ligustrum lucidum, Cell Proliferation, Pharmacology, Osteoblasts, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, 3T3 Cells, General Medicine, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Oleaceae, Molecular Medicine |
| الوصف: | Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6'-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells. |
| تدمد: | 1477-2213 1028-6020 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caaa6641b63fab4e0d1f86ceaddb1d0 https://doi.org/10.1080/10286020.2018.1454438 |
| رقم الأكسشن: | edsair.doi.dedup.....5caaa6641b63fab4e0d1f86ceaddb1d0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14772213 10286020 |
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