Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties
| العنوان: | Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties |
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| المؤلفون: | Nefeli Papadopoulou-Fermeli, Eleni A. Georgakopoulou, Evdokia Galata, Evangelia A. Pavlatou, Maria-Emmanouela Kassalia |
| المصدر: | Materials Volume 12 Issue 16 Materials, Vol 12, Iss 16, p 2589 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, Scanning electron microscope, Infrared, Nanoparticle, N-doped TiO2, 02 engineering and technology, anticancer, 010402 general chemistry, lcsh:Technology, 01 natural sciences, Article, chemistry.chemical_compound, Dynamic light scattering, General Materials Science, lcsh:Microscopy, IP microgel, visible light, lcsh:QC120-168.85, lcsh:QH201-278.5, lcsh:T, technology, industry, and agriculture, pNiPam, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Chemical engineering, lcsh:TA1-2040, Transmission electron microscopy, Fe-doped TiO2, drug delivery, Titanium dioxide, Fe,N-doped TiO2, Photocatalysis, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, lcsh:Engineering (General). Civil engineering (General), 0210 nano-technology, lcsh:TK1-9971, photocatalysis, sol gel, Visible spectrum |
| الوصف: | In this study, the synthesis of smart, polymerically embedded titanium dioxide (TiO2) nanoparticles aimed to exhibit photo-induced anticancer properties under visible light irradiation is investigated. The TiO2 nanoparticles were prepared by utilizing the sol gel method with different dopants, including nitrogen (N-doped), iron (Fe-doped), and nitrogen and iron (Fe,N-doped). The dopants were embedded in an interpenetrating (IP) network microgel synthesized by stimuli responsive poly (N-Isopropylacrylamide-co-polyacrylicacid)&ndash pNipam-co-PAA forming composite particles. All the types of produced particles were characterized by X-ray powder diffraction, micro-Raman, Fourier-transform infrared, X-ray photoelectron, ultra-violet-visible spectroscopy, Field Emission Scanning Electron, Transmission Electron microscopy, and Dynamic Light Scattering techniques. The experimental findings indicate that the doped TiO2 nanoparticles were successfully embedded in the microgel. The N-doped TiO2 nano-powders and composite particles exhibit the best photocatalytic degradation of the pollutant methylene blue under visible light irradiation. Similarly, the highly malignant MDA-MB-231 breast cancer epithelial cells were susceptible to the inhibition of cell proliferation at visible light, especially in the presence of N-doped powders and composites, compared to the non-metastatic MCF-7 cells, which were not affected. |
| وصف الملف: | application/pdf |
| تدمد: | 1996-1944 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbfa2a5e8a241389e2783e99b1dc64b https://doi.org/10.3390/ma12162589 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5cbfa2a5e8a241389e2783e99b1dc64b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19961944 |
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