Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries
| العنوان: | Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
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| المؤلفون: | Ameli Tropé, Gry Baadstrand Skare, Sirpa Heinävaara, Tytti Sarkeala, Ágúst Ingi Ágústsson, Maiju Pankakoski, Ahti Anttila, Veli-Matti Partanen, Joakim Dillner, Stefan Lönnberg, Jiangrong Wang |
| المصدر: | Journal of Medical Screening. 28:464-471 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Registry study, Uterine Cervical Neoplasms, Alphapapillomavirus, Cervical cancer screening, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Cytology, Cancer screening, Humans, Medicine, 030212 general & internal medicine, Human papillomavirus, Papillomaviridae, Early Detection of Cancer, Vaginal Smears, Cervical cancer, Cervical screening, business.industry, Obstetrics, Health Policy, Papillomavirus Infections, Human papillomavirus screening, Public Health, Environmental and Occupational Health, Uterine Cervical Dysplasia, medicine.disease, Cross-Sectional Studies, Colposcopy, 030220 oncology & carcinogenesis, Female, business |
| الوصف: | Objective To compare primary test positivity in cytology and human papillomavirus-based screening between different Nordic cervical cancer screening programs using harmonized register data. Methods This study utilized individual-level data available in national databases in Finland, Iceland, Norway, and Sweden. Cervical test data from each country were converted to standard format and aggregated by calculating the number of test episodes for every test result for each calendar year and one-year age group and test method. Test positivity was estimated as the proportion of positive test results of all primary test episodes with a valid test result for “any positive” and “clearly positive” results. Results The age-adjusted rate ratio for any positive test results in primary human papillomavirus-based screening compared to cytology was 1.66 (95% CI 1.64–1.68). The age-adjusted rate ratio for clearly positive test results was 1.02 (95% CI 1.00–1.05). A decreasing rate ratio by age was seen in both any positive and clearly positive test results. Test positivity increased over time in Iceland, Norway, and Sweden but slightly decreased in Finland. Conclusions The probability of any positive test result was higher in human papillomavirus testing than in primary cytology, even though the cross-sectional detection of a clearly positive test result was the same. Human papillomavirus testing can still lead to an improved longitudinal sensitivity through a larger number of follow-up tests and the opportunity to identify women with a persistent human papillomavirus infection. Further research on histologically verified precancerous lesions is needed in primary as well as repeat testing. |
| تدمد: | 1475-5793 0969-1413 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce82308d83c68e7e6899614fbe440e5 https://doi.org/10.1177/0969141321992404 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5ce82308d83c68e7e6899614fbe440e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14755793 09691413 |
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