Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
| العنوان: | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
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| المؤلفون: | Jae Hun Sim, Joo Yun Kim, Woo Nam, Hyeon Ji Kim, Park Soo Dong, Chu Hyun Bae, Jisoo Kim, Jung Lyoul Lee, Soo A Kim, Bora Nam |
| المصدر: | PLoS ONE, Vol 15, Iss 4, p e0231268 (2020) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Biochemistry, Database and Informatics Methods, 0302 clinical medicine, Medicine and Health Sciences, Bifidobacterium, Skin, Extracellular Matrix Proteins, Multidisciplinary, biology, Gene Ontologies, Zonulin, Genomics, Biodiversity, Middle Aged, Extracellular Matrix, Intestines, 030220 oncology & carcinogenesis, Medicine, Female, medicine.symptom, Anatomy, Cellular Structures and Organelles, Sequence Analysis, Research Article, Adult, Bioinformatics, Science, Sequence Databases, Inflammation, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Young Adult, Immune system, Downregulation and upregulation, medicine, Genetics, Humans, Aged, Intestinal permeability, Tumor Necrosis Factor-alpha, Probiotics, Biology and Life Sciences, Computational Biology, Proteins, Cell Biology, biology.organism_classification, medicine.disease, Genome Analysis, Extracellular Matrix Composition, Gastrointestinal Microbiome, Gastrointestinal Tract, 030104 developmental biology, Biological Databases, Gene Ontology, Calprotectin, Caco-2 Cells, Digestive System, Lactobacillus plantarum, Biomarkers |
| الوصف: | Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cefdfc0d266f6b3f7112337786f926b https://doaj.org/article/9132bce0339942c3a1ff9d0fdf54080d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5cefdfc0d266f6b3f7112337786f926b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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