Anopheles Salivary Biomarker to Assess Malaria Transmission Risk Along the Thailand-Myanmar Border
| العنوان: | Anopheles Salivary Biomarker to Assess Malaria Transmission Risk Along the Thailand-Myanmar Border |
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| المؤلفون: | Gilles Cottrell, Daniel M. Parker, Vincent Corbel, Theeraphap Chareonviriyaphap, Anne Poinsignon, Franck Remoue, Phubeth Ya-umphan, François Nosten, Cécile Brengues, Dominique Cerqueira |
| المساهمون: | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Mahidol Oxford Tropical Medicine Research Unit, University of Oxford [Oxford]-Mahidol University [Bangkok], Institut de Recherche pour le Développement (IRD), Transmission-Interactions-Adaptations hôtes/vecteurs/pathogènes (MIVEGEC-TRIAD), Evolution des Systèmes Vectoriels (ESV), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Vector Control Group (MIVEGEC-VCG), Kasetsart University - KU (THAILAND), Kasetsart University (KU) |
| المصدر: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2016, pp.jiw543. ⟨10.1093/infdis/jiw543⟩ |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Myanmar, law.invention, Cohort Studies, 0302 clinical medicine, law, Immunology and Allergy, Child, Salivary biomarkers, Malaria vector, ComputingMilieux_MISCELLANEOUS, response, transmission, Salivary Biomarker, Anopheles, Middle Aged, Thailand, 3. Good health, Infectious Diseases, Transmission (mechanics), Child, Preschool, Insect Proteins, [SDV.IMM]Life Sciences [q-bio]/Immunology, Biomarker (medicine), Female, human antibody, Adult, malaria vectors, Adolescent, 030231 tropical medicine, Biology, Human Immunoglobulin G, Young Adult, 03 medical and health sciences, Malaria transmission, parasitic diseases, Major Article, medicine, Animals, Humans, Salivary Proteins and Peptides, Aged, Infant, Newborn, Thailand-Myanmar border, Infant, Insect Bites and Stings, Environmental Exposure, medicine.disease, biology.organism_classification, Malaria, 030104 developmental biology, Immunoglobulin G, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, gSG6-P1, Biomarkers, Demography |
| الوصف: | Author(s): Ya-Umphan, Phubeth; Cerqueira, Dominique; Parker, Daniel M; Cottrell, Gilles; Poinsignon, Anne; Remoue, Franck; Brengues, Cecile; Chareonviriyaphap, Theeraphap; Nosten, Francois; Corbel, Vincent | Abstract: BackgroundThe modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk among humans of exposure to Anopheles bites.MethodsSerologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. More than 9400 blood specimens were collected in filter papers from all inhabitants at baseline and then every 3 months thereafter, for up to 18 months, for analysis by enzyme-linked immunosorbent assay. The relationship between the intensity of the human antibody response and entomological indicators of transmission (human biting rates and entomological inoculation rates [EIRs]) was studied using a multivariate 3-level mixed model analysis. Heat maps for human immunoglobulin G (IgG) responses for each village and survey time point were created using QGIS 2.4.ResultsThe levels of IgG response among participants varied significantly according to village, season, and age (Pl.001) and were positively associated with the abundance of total Anopheles species and primary malaria vectors and the EIR (Pl.001). Spatial clusters of high-IgG responders were identified across space and time within study villages.ConclusionsThe gSG6-P1 biomarker has great potential to address the risk of transmission along the Thailand-Myanmar border and represents a promising tool to guide malaria interventions. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf34f97857b0095b3a608d63090d90b https://doi.org/10.1093/infdis/jiw543 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5cf34f97857b0095b3a608d63090d90b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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