Clinical information and management status of de novo stage IV breast cancer patients: a Chinese multicenter investigation (CSBrS-002)
| العنوان: | Clinical information and management status of de novo stage IV breast cancer patients: a Chinese multicenter investigation (CSBrS-002) |
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| المؤلفون: | Ang Zheng, Bao-Liang Guo, Jian-Guo Zhang, Feng Jin, Chinese Society of Breast Surgery, Yuan-Yuan Ji |
| المصدر: | Chinese Medical Journal Chinese Medical Journal, Vol 134, Iss 13, Pp 1569-1575 (2021) |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, China, medicine.medical_specialty, Receptor, ErbB-2, Breast surgery, medicine.medical_treatment, Estrogen receptor, Breast Neoplasms, Multicenter investigation, Metastasis, Breast cancer, De novo stage IV breast cancer, Internal medicine, Biomarkers, Tumor, medicine, Humans, Family history, Chinese Society of Breast Surgery, Mastectomy, Retrospective Studies, Systemic therapy, Metastatic site, business.industry, Bone metastasis, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, Prognosis, medicine.disease, Chemotherapy regimen, Medicine, Female, Receptors, Progesterone, business |
| الوصف: | Background:. Although de novo stage IV breast cancer is so far incurable, it has entered an era of individualized treatment and chronic disease management. Based on systemic treatment, whether the surgical resection of primary or metastatic foci of de novo stage IV breast cancer can bring survival benefits is currently controversial. We aimed to explore the clinicopathological factors and current status of the management of de novo stage IV breast cancer in China to provide a reference for clinical decisions. Methods:. Based on the assistance of Chinese Society of Breast Surgery, a retrospective study was conducted to analyze the clinical data of patients with de novo stage IV breast cancer in 33 centers from January 2017 to December 2018. The relationship between basic characteristic (age, menstrual status, family history, reproductive history, pathological type, estrogen receptor [ER] status, progesterone receptor [PR] status, human epidermal growth factor receptor 2 [HER2] status, Ki-67 percentage, and molecular subtype), and metastasis sites (lung metastasis, liver metastasis, and bone metastasis) was examined by Pearson Chi-square tests. Results:. A total of 468 patients with de novo stage IV breast cancer were enrolled. The median age of the enrolled patients was 51.5 years. The most common pathological type of primary lesion was invasive carcinoma (97.1%). Luminal A, luminal B, HER2 overexpressing, and triple-negative subtypes accounted for 14.3%, 51.8%, 22.1%, and 11.8% of all cases, respectively. Age, PR status, and HER2 status were correlated with lung metastasis (χ2 = 6.576, 4.117, and 8.643 and P = 0.037, 0.043, and 0.003, respectively). Pathological type, ER status, PR status, and molecular subtype were correlated with bone metastasis (χ2 = 5.117, 37.511, 5.224, and 11.603 and P = 0.024 |
| تدمد: | 2542-5641 0366-6999 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d27c94da2516d47f178cda540c35deb https://doi.org/10.1097/cm9.0000000000001415 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5d27c94da2516d47f178cda540c35deb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25425641 03666999 |
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