Effect of two oral doses of 17beta-estradiol associated with dydrogesterone on thrombin generation in healthy menopausal women: a randomized double-blind placebo-controlled study
| العنوان: | Effect of two oral doses of 17beta-estradiol associated with dydrogesterone on thrombin generation in healthy menopausal women: a randomized double-blind placebo-controlled study |
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| المؤلفون: | Grigoris T. Gerotziafas, Eric Dasque, Jean-Louis Démolis, Dahlia Torchin, Karine Lacut, Annie Robert, Faiez Zannad, Tabassome Simon, Alexandra Rousseau, Christian Libersa, Ismail Elalamy |
| المساهمون: | Service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'hématologie biologique [CHU Tenon], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC CHU ( Lille)/inserm, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Signalisation cellulaire, dynamique circulatoire et athérosclérose précoce (SCDCAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Service d'Histologie-Biologie tumorale [Hôpital Tenon], Université Pierre et Marie Curie - Paris 6 (UPMC) |
| المصدر: | Fundamental and Clinical Pharmacology Fundamental and Clinical Pharmacology, Wiley, 2010, 24 (2), pp.239-45. ⟨10.1111/j.1472-8206.2009.00747.x⟩ |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Time Factors, MESH: Menopause, Administration, Oral, 030204 cardiovascular system & hematology, Dydrogesterone, MESH: Estrogens, MESH: Dose-Response Relationship, Drug, MESH: Thrombin, 0302 clinical medicine, Oral administration, Pharmacology (medical), MESH: Double-Blind Method, 030212 general & internal medicine, Clotting factor, MESH: Aged, MESH: Middle Aged, Estradiol, Thrombin, Middle Aged, Blood Coagulation Factors, 3. Good health, Menopause, MESH: Administration, Oral, Drug Therapy, Combination, Female, MESH: Estradiol, medicine.drug, medicine.medical_specialty, medicine.drug_class, Placebo, 03 medical and health sciences, Tissue factor, Double-Blind Method, Internal medicine, medicine, Humans, Aged, Pharmacology, MESH: Humans, Dose-Response Relationship, Drug, business.industry, MESH: Time Factors, MESH: Blood Coagulation Factors, Estrogens, medicine.disease, MESH: Drug Therapy, Combination, Endocrinology, Estrogen, MESH: Progestins, MESH: Dydrogesterone, Progestins, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience; Oral hormone therapy is associated with an increased risk of venous thrombosis. Drug agencies recommend the use of the lowest efficient dose to treat menopausal symptoms for a better risk/ratio profile, although this profile has not been totally investigated yet. The aim of the study was to compare the effect of the standard dose of 17beta-estradiol to a lower one on thrombin generation (TG). In a 2-month study, healthy menopausal women were randomized to receive daily 1mg or 2 mg of 17beta-estradiol (E1, n = 24 and E2, n = 26; respectively) with 10 mg dydrogesterone or placebo (PL, n = 22). Plasma levels factors VII, X, VIII and II were assessed before and after treatment as well as Tissue factor triggered TG, which allows the investigation of the different phases of coagulation process. The peak of thrombin was higher in hormone therapy groups (E1: 42.39 +/- 50.23 nm, E2: 31.08 +/- 85.86 nm vs. 10.52 +/- 40.63 nm in PL, P = 0.002 and P = 0.01). Time to reach the peak was also shortened (PL: 0.26 +/- 0.69 min vs. E1: -0.26 +/- 0.80 min, E2: -0.55 +/- 0.79 min, P |
| تدمد: | 1472-8206 0767-3981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3379ab5d35c48006039d395a3b1949 https://pubmed.ncbi.nlm.nih.gov/19719551 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5d3379ab5d35c48006039d395a3b1949 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14728206 07673981 |
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