Sulfur - fluorine bond in PET radiochemistry
| العنوان: | Sulfur - fluorine bond in PET radiochemistry |
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| المؤلفون: | Bo Zhang, Lidia Matesic, Alison T. Ung, Andrew T King, Benjamin H. Fraser, Giancarlo Pascali, Andrea J. Robinson |
| المصدر: | Ejnmmi Radiopharmacy and Chemistry EJNMMI Radiopharmacy and Chemistry, Vol 2, Iss 1, Pp 1-18 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, Fluorosulfate, lcsh:R895-920, Sulfurhexafluoride, chemistry.chemical_element, Review, Fluoride relay, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, Organic molecules, Sulfonyl fluoride, Moiety, Organic chemistry, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Reactivity (chemistry), Pharmacology, 010405 organic chemistry, Chemistry, Radiochemistry, lcsh:RM1-950, Sulfur, 0104 chemical sciences, Sulfur-fluorine bond, lcsh:Therapeutics. Pharmacology, 18F, PET, Reagent, Fluorine, Deoxyfluorination |
| الوصف: | The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications. |
| وصف الملف: | application/pdf |
| تدمد: | 2365-421X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d59148d74ce61e276e14bd204b1e705 https://pubmed.ncbi.nlm.nih.gov/29503850 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5d59148d74ce61e276e14bd204b1e705 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 2365421X |
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