Prevalence of conditions associated with human immunodeficiency and hepatitis virus infections among persons with haemophilia, 2001-2003
| العنوان: | Prevalence of conditions associated with human immunodeficiency and hepatitis virus infections among persons with haemophilia, 2001-2003 |
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| المؤلفون: | James French, Gilbert C. White, Joan Cox Gill, Felicia Kiplinger, Richard Lipton, James J. Goedert, Melinda E Nolte, Charles Cooper, Brittan Browning, Kathryn Galli, Nigel S. Key, Anastasia Karafoulidou, Craig M. Kessler, Christine Guelcher, Michael W. Fried, Howard A. Britton, Amy D. Shapiro, Catherine S. Manno, Naomi L.C. Luban, Aime L. Grimsley, Cindy A. Leissinger, Johanna McCarthy, John J. Hutter, Alexis A. Thompson, Dorine Belliveau, Michael Lammer, Anne L. Angiolillo, Keith Hoots, Zale P. Bernstein, Willis H. Navarro, Anastasia E. Lee, Jeanne M. Lusher, Ilene Goldberg, Muriel Herr, Linda Percy, Gina Stack, Kevin McRedmond, Kay Miller, Amanda Wade, Christine Pece, Richard S. Lemons, Sandra Hibner, Deborah L Brown, Jodie Nelson, Cecilia V. Schmidt, Charles Sexauer, Anita Smith, Prasad Matthew, Barbara A. Konkle, Kenneth E. Sherman, Sheldon H. Rubin, Hernan Sabio, Vicky Hannemann, M. Ullman, Judy A. Bagato, Donna DiMichele, Jerry S. Powell, Regina Butler, Marilyn J. Manco-Johnson, Patti Noblet, Lori Laudenbach, Kathi Cobb, Madeline Heffner, Arthur R. Thompson, Marcus E. Carr, Ralph A. Gruppo, Sheryl Giambartolomei, Suzi Greer, J. E. Palascak, Donald Lilley, Jaime Siegel, Louis M. Aledort, Michael M. Lederman, Marge Halley, Nirmala Vijayanathan, Linda Belling, Jessie Roth, Steven Klintworth, Shirley Bleak, Diane J. Nugent, Michael D. Tarantino, Jorge DiPaolo, Lawrence Jardine, Rathi V. Iyer, Mary Lou Damiano, Karen Scott, Anne T. Neff, Steven Faust, Susan Gamerman, Hans Joachim Reimers, Eric H. Kraut, Marcia Schwartz, M. Elaine Eyster, Gillian Jenkins, Marianne McDaniel, Leslie Witkoff, James P. Steinberg, Marion Dugdale, Janice S. Withycombe |
| المصدر: | Haemophilia. 11:516-528 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Alcohol Drinking, Pancytopenia, Hepatitis C virus, Population, HIV Infections, Hemophilia A, Haemophilia, medicine.disease_cause, Antiviral Agents, Hemophilia B, chemistry.chemical_compound, Hepatitis B, Chronic, Antiretroviral Therapy, Highly Active, Internal medicine, medicine, Humans, education, Genetics (clinical), Aged, Subclinical infection, Aged, 80 and over, Hepatitis B virus, education.field_of_study, business.industry, Ribavirin, virus diseases, Hematology, General Medicine, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Hepatitis B, medicine.disease, von Willebrand Diseases, Cross-Sectional Studies, chemistry, Immunology, HIV-1, Female, business, Hepatomegaly |
| الوصف: | Before the mid-1980s, haemophilia often was unknowingly treated with contaminated plasma products, resulting in high rates of human immunodeficiency virus (HIV-1), hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To estimate the impact of these infections, a new cohort was established. All HCV-seropositive patients, age 13-88 years, at 52 comprehensive haemophilia treatment centres were eligible. Cross-sectional data collected during April 2001 to January 2004 (median June 2002) were analysed. Plasma HIV-1 and HCV RNA were quantified by polymerase chain reaction. Highly active antiretroviral therapy (HAART) was defined as use of at least three recommended medications. Among 2069 participants, 620 (30%) had HIV-1. Of 1955 with known HBV status, 814 (42%) had resolved HBV and 90 (4.6%) were HBV carriers. Although 80% of the HIV-1-positive participants had > or = 200 CD4+ cells microL(-1), only 59% were on HAART. HIV-1 RNA was undetectable in 23% of those not taking antiretroviral medications. Most (72%) participants had received no anti-HCV therapy. HCV RNA was detected less frequently (59%) among participants treated with standard interferon plus ribavirin (P = 0.0001) and more frequently among HIV-1-positive than HIV-1-negative participants (85% vs. 70%, P < 0.0001). HIV-1-positive participants were more likely to have pancytopenia and subclinical hepatic abnormalities, as well as persistent jaundice, hepatomegaly, splenomegaly and ascites. HAART recipients did not differ from HIV-negative participants in the prevalence of ascites. The clinical abnormalities were more prevalent with older age but were not confounded by HBV status or self-reported alcohol consumption. Eleven participants presented with or previously had hepatocellular carcinoma or non-Hodgkin lymphoma. Although prospective analysis is needed, our data reveal the scale of hepatic and haematological disease that is likely to manifest in the adult haemophilic population during the coming years unless most of them are successfully treated for HIV-1, HCV or both. |
| تدمد: | 1365-2516 1351-8216 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8c4b2f8f2af6fe1653d8d9cdd9225a https://doi.org/10.1111/j.1365-2516.2005.01138.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5d8c4b2f8f2af6fe1653d8d9cdd9225a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652516 13518216 |
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