التفاصيل البيبلوغرافية
العنوان:
MicroRNAs and Xenobiotic Toxicity: An Overview
المؤلفون:
Satheeswaran Balasubramanian , Ekambaram Perumal , Vignesh Jeyamanickavel Mathan , Kanmani Gunasekaran , Saranyadevi Sasidharan
المصدر:
Toxicology Reports Toxicology Reports, Vol 7, Iss, Pp 583-595 (2020)
سنة النشر:
2020
مصطلحات موضوعية:
microRNAs: Potential biomarkers of toxicity , Nrf2, Nuclear factor erythroid 2-related factor 2 , Aβ, Amyloid Beta , Toxicology , 01 natural sciences , Non-coding RNAs , AHR, Aryl Hydrocarbon Receptor , 0302 clinical medicine , CDK6, Cyclin-dependent kinase 6 , NMDAR, N-methyl-d-aspartate receptor , TP53, Tumor protein 53 , BaP, Benzo[a]pyrene , NPs, Nanoparticles , Regulation of gene expression , Hpf, Hours post fertilization , qRT-PCR, quantitative Real Time-Polymerase Chain Reaction , CDKN1b, Cyclin-dependent kinase Inhibitor 1B , Wnt, Wingless-related integration site , HSPA1A, Heat shock 70 kDa protein 1 , IL1R1, Interleukin 1 receptor, type 1 , ER, Endoplasmic Reticulum , PDCD4, Programmed cell death protein 4 , MC-RR, Microcystin-Arginine Arginine , RNAi, RNA interference , DGCR8, DiGeorge syndrome chromosomal [or critical] region 8 , Epigenetics , GTP, Guanosine triphosphate , bcl2l11, B-cell lymphoma-2-like protein 11 , TCDD, 2,3,7,8-Tetrachlorodibenzodioxin , RNA - Ribonucleic acid , lncRNAs, Long non-coding RNA , NFKBAP, NFKB Activating protein-1 , COPD, Chronic obstructive pulmonary disease , PM2.5, Particulate Matter2.5 , Environment , WHO, World Health Organization , 03 medical and health sciences , MRE, MicroRNA Response Elements , microRNA , SPIONs, Superparamagnetic Iron Oxide Nanoparticles , AMPK, Adenosine Monophosphate-activated protein kinase , lcsh:Toxicology. Poisons , NASH, Non-alcoholic steatohepatitis , CDK, Cyclin-dependent Kinase , CEC, Contaminants of Emerging Concern , RNase III, Ribonuclease III , LRP-1-, Low density lipoprotein receptor-related protein 1 , MC-LR, Microcystin-Leucine Arginine , CCNB1, Cyclin B1 , Ag, Silver , SiO2, Silicon dioxide , chemistry , LIN28B, Lin-28 homolog B , TRBP, Transactivation Response RNA Binding Protein , 030217 neurology & neurosurgery , Ahr aryl hydrocarbon receptor , Biomarkers , COX2, Cyclooxygenase-2 , Au, Gold , ZEA, Zearalanone , Mn, Manganese , NF- ҡB, Nuclear Factor kappa-light-chain-enhancer of activated B cells , Health, Toxicology and Mutagenesis , Grp78/BIP, Binding immunoglobulin protein , 010501 environmental sciences , UTR, Untranslated region , chemistry.chemical_compound , ARRB1, Arrestin beta 1 , RISC, RNA-induced silencing complex , Zn, Zinc , CTGF, Connective Tissue Growth Factor , NET1, Neuroepithelial Cell Transforming 1 , BNIP3−3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 , DNA, Deoxy ribonucleic acid , PFAS, Poly-fluoroalkyl substances , mRNA, Messenger RNA , ripk 1, Receptor-interacting serine/threonine-protein kinase 1 , Toxicity , Fadd, Fas-associated protein with death domain , IL-6, Interleukin 6 , SOLiD, Sequencing by Oligonucleotide Ligation and Detection , Al2O3, Aluminium oxide , ceRNA, Competing endogenous RNA , Computational biology , Biology , SEMA6D, Semaphorin-6D , BCB, Blood-cerebrospinal fluid barrier , ADAMTS9, A disintegrin and metalloproteinase with thrombospondin motifs 9 , CDC25A, M-phase inducer phosphatase 1 , lcsh:RA1190-1270 , CDK1, Cyclin-dependent kinase 1 , DON, Deoxynivalenol , RNA, Ribonucleic acid , TNF-α, Tumor necrosis factor – alpha , 0105 earth and related environmental sciences , ComputingMethodologies_COMPUTERGRAPHICS , miRNA, MicroRNA , MAPK, Mitogen Activated Protein Kinase , Gene regulation , CDC25C, M-phase inducer phosphatase 3 , Xenobiotic , MiRNA biogenesis
الوصف:
Graphical abstract Highlights • miRNAs are key regulators of gene expression at both transcription and translation. • The role of miRNAs in xenobiotic toxicity and its potential as biomarkers are being explored. • In spite of numerous studies, the complex mechanism of miRNA biogenesis and its regulation remains unclear. The advent of new technologies has paved the rise of various chemicals that are being employed in industrial as well as consumer products. This leads to the accumulation of these xenobiotic compounds in the environment where they pose a serious threat to both target and non-target species. miRNAs are one of the key epigenetic mechanisms that have been associated with toxicity by modulating the gene expression post-transcriptionally. Here, we provide a comprehensive view on miRNA biogenesis, their mechanism of action and, their possible role in xenobiotic toxicity. Further, we review the recent in vitro and in vivo studies involved in xenobiotic exposure induced miRNA alterations and the mRNA-miRNA interactions. Finally, we address the challenges associated with the miRNAs in toxicological studies.
تدمد:
2214-7500
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9ee14a85356d66a24aeb2b5ac399f7 https://pubmed.ncbi.nlm.nih.gov/32426239
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....5d9ee14a85356d66a24aeb2b5ac399f7
قاعدة البيانات:
OpenAIRE