Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation
| العنوان: | Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation |
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| المؤلفون: | Eleanor H. Simpson, Holly Moore, Pierre Trifilieff, Peter D. Balsam, Bo Feng, Vanessa Winiger, Kathleen M. Taylor, Ryan D. Ward, Diana Martinez, Jonathan A. Javitch, Eneko Urizar |
| المساهمون: | Inconnu |
| المصدر: | Molecular Psychiatry Molecular Psychiatry, 2013, 18 (9), pp.1025—1033. ⟨10.1038/mp.2013.57⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | media_common.quotation_subject, Conditioning, Classical, Genetic Vectors, Green Fluorescent Proteins, Striatum, Nucleus accumbens, Tritium, Article, Nucleus Accumbens, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Reward, Postsynaptic potential, Dopamine, Dopamine receptor D2, medicine, Animals, Attention deficit hyperactivity disorder, Receptor, Molecular Biology, 030304 developmental biology, media_common, Mice, Knockout, Analysis of Variance, Motivation, 0303 health sciences, Receptors, Dopamine D2, Addiction, medicine.disease, Mice, Inbred C57BL, Psychiatry and Mental health, Gene Expression Regulation, Conditioning, Operant, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Microtubule-Associated Proteins, Neuroscience, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation, including obesity, addiction, and attention deficit hyperactivity disorder. Since disruption of D2R signaling in the ventral striatum – including the Nucleus Accumbens (NAc) - impairs motivation, we sought to determine whether potentiating postsynaptic D2R-dependent signaling in the NAc would improve motivation. In this study, we used a viral vector strategy to overexpress postsynaptic D2Rs in either the NAc or the dorsal striatum. We investigated the effects of D2R overexpression on instrumental learning, willingness to work, use of reward value representations and modulation of motivation by reward associated cues. Overexpression of postsynaptic D2R in the NAc selectively increased motivation without altering consummatory behavior, the representation of the value of the reinforcer, or the capacity to use reward associated cues in flexible ways. In contrast, D2R overexpression in the dorsal striatum did not alter performance on any of the tasks. Thus, consistent with numerous studies showing that reduced D2R signaling impairs motivated behavior, our data show that post-synaptic D2R overexpression in the NAc specifically increases an animal’s willingness to expend effort to obtain a goal. Taken together, these results provide insight into the potential impact of future therapeutic strategies that enhance D2R signaling in the NAc. |
| تدمد: | 1476-5578 1359-4184 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da50e826fee4637f9ab65cb85559466 https://doi.org/10.1038/mp.2013.57 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5da50e826fee4637f9ab65cb85559466 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765578 13594184 |
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