Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi
| العنوان: | Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi |
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| المؤلفون: | Chu-Hung Lin, Hsun-Shuo Chang, Shuen-Shin Yang, Ho-Cheng Wu, Tsong-Long Hwang, Shiou-Ling Li |
| المصدر: | Molecules, Vol 25, Iss 4149, p 4149 (2020) Molecules Volume 25 Issue 18 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lignan, medicine.drug_class, Stereochemistry, lauraceae, Pharmaceutical Science, 01 natural sciences, Japonica, Anti-inflammatory, Machilus japonica var. kusanoi, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, medicine, Physical and Theoretical Chemistry, anti-inflammatory activity, Cytochalasin B, Lignan, butanolide, biology, 010405 organic chemistry, Superoxide, Organic Chemistry, Elastase, Absolute configuration, food and beverages, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Phytochemical, Chemistry (miscellaneous), Molecular Medicine |
| الوصف: | In a series of anti-inflammatory screenings of lauraceous plants, the methanolic extract of the leaves of Machilus japonica var. kusanoi (Hayata) J.C. Liao showed potent inhibition on both superoxide anion generation and elastase release in human neutrophils. Bioassay-guided fractionation of the leaves of M. japonica var. kusanoi led to the isolation of twenty compounds, including six new butanolides, machinolides A&ndash F (1&ndash 6), and fourteen known compounds (7&ndash 20). Their structures were characterized by 1D and 2D NMR, UV, IR, CD, and MS data. The absolute configuration of the new compounds were unambiguously confirmed by single-crystal X-ray diffraction analyses (1, 2, and 3) and Mosher&rsquo s method (4, 5, and 6). In addition, lignans, (+)-eudesmin (11), (+)-methylpiperitol (12), (+)-pinoresinol (13), and (+)-galbelgin (16) exhibited inhibitory effects on N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation in human neutrophils with IC50 values of 8.71 ± 0.74 &mu M, 2.23 ± 0.92 &mu M, 6.81 ± 1.07 &mu M, and 7.15 ± 2.26 &mu M, respectively. The results revealed the anti-inflammatory potentials of Formosan Machilus japonica var. kusanoi. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe6f6fa572b6aef6fd23d8f7ab2115 https://www.mdpi.com/1420-3049/25/18/4149 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5dbe6f6fa572b6aef6fd23d8f7ab2115 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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