When two wrongs make a right: synchronized neuronal bursting from combined electrical and inhibitory coupling
| العنوان: | When two wrongs make a right: synchronized neuronal bursting from combined electrical and inhibitory coupling |
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| المؤلفون: | Kevin Daley, Igor Belykh, Reimbay Reimbayev |
| المصدر: | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 375:20160282 |
| بيانات النشر: | The Royal Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | General Mathematics, media_common.quotation_subject, Models, Neurological, Action Potentials, General Physics and Astronomy, Neocortex, Biology, Synaptic Transmission, 01 natural sciences, 010305 fluids & plasmas, Bursting, Biological Clocks, Perception, 0103 physical sciences, Two wrongs make a right, Animals, Humans, Computer Simulation, Cortical Synchronization, 010306 general physics, media_common, Feedback, Physiological, Neurons, General Engineering, Neural Inhibition, Articles, Inhibitory coupling, Nerve Net, Neuroscience |
| الوصف: | Synchronized cortical activities in the central nervous systems of mammals are crucial for sensory perception, coordination and locomotory function. The neuronal mechanisms that generate synchronous synaptic inputs in the neocortex are far from being fully understood. In this paper, we study the emergence of synchronization in networks of bursting neurons as a highly non-trivial, combined effect of electrical and inhibitory connections. We report a counterintuitive find that combined electrical and inhibitory coupling can synergistically induce robust synchronization in a range of parameters where electrical coupling alone promotes anti-phase spiking and inhibition induces anti-phase bursting. We reveal the underlying mechanism, which uses a balance between hidden properties of electrical and inhibitory coupling to act together to synchronize neuronal bursting. We show that this balance is controlled by the duty cycle of the self-coupled system which governs the synchronized bursting rhythm. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’. |
| تدمد: | 1471-2962 1364-503X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dca20311896157a5c17a90b219c4bc5 https://doi.org/10.1098/rsta.2016.0282 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5dca20311896157a5c17a90b219c4bc5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712962 1364503X |
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