أعرض في EDS

Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities

التفاصيل البيبلوغرافية
العنوان: Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities
المؤلفون: Wenbao Li, Hou Yingwei, Sun Tianwen, Zhongpeng Ding, Mingxu Ma, Huashi Guan, Wang Shixiao
المصدر: Molecular diversity. 21(3)
سنة النشر: 2016
مصطلحات موضوعية: Stereochemistry, Cell Survival, Proton Magnetic Resonance Spectroscopy, chemistry.chemical_element, Antineoplastic Agents, Diketopiperazines, 01 natural sciences, Jurkat cells, Catalysis, Mass Spectrometry, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Jurkat Cells, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, Humans, Physical and Theoretical Chemistry, Carbon-13 Magnetic Resonance Spectroscopy, Molecular Biology, Cell Proliferation, Antitumor activity, Molecular Structure, 010405 organic chemistry, Drug discovery, Organic Chemistry, General Medicine, Fluorine, Deuterium, Combinatorial chemistry, 0104 chemical sciences, chemistry, 030220 oncology & carcinogenesis, Information Systems, Plinabulin
الوصف: Deuterium-enriched and fluorine-substituted compounds have been widely applied in drug discovery due to their advantages in the studies of clinical pharmacokinetics and metabolic profiles. Herein we synthesized a library of deuterated and fluorine-substituted plinabulin derivatives, and all 15 D- or F-compounds were characterized by MS, [Formula: see text] NMR and [Formula: see text]. Their antitumor activities were evaluated against human Jurkat T lymphocyte cells.
تدمد: 1573-501X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddae053ef544ad5e37bd4ef658a02da
https://pubmed.ncbi.nlm.nih.gov/28488201
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....5ddae053ef544ad5e37bd4ef658a02da
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1573501X